Hi, Based from the information provided it seems that you are suffering from difficult to control high blood pressure. Now let me give you some more information about the medication you are taking and what may help to lower you blood pressure and why taking aspirin did not had any change to your blood pressure. 1) LOSARTAN AND NORVASC are the medication which acts on kidney which STOPS certain chemical fromation that signals heart to work heart and constriction of blood vessels. In turn helps lowering blood pressure. 2) HTCZ - is medication which is know as water pill or basically make you pee a lot, getting rid of excess of water from blood so that by lowering blood volume the blood pressure goes down. 3) ASPIRIN - is blood thinner and has no role in lowering blood pressure, its a pill which will cause the blood not to clot. Hence you did not see any pressure changes after taking aspirin. Here are few things that can help reduction of blood pressure other then medication a) STRESS RELIEF - yoga / meditation b) LESS / NO SALT CONSUMPTION. c) LONG WALK AT slow strides and taking long breaths. d) Regular exercises e) Healthy food and reducing weight helps a great deal. Hope I was able to address all of your concern. Dr. JAY PATEL