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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Have Hepatitis C Genotype 3A. Elevated Liver Enzymes. USG Showing Mildly Coarse Liver. Took Ribavarin. Have Pedal Edema. Advice?

I am 38 years old. I gad hep c genotype3a. Elevated liver enzymes. Normal bilirubin,albumin and INR. USG suggested mildly coarse liver. I took six months course of peg ifn n ribavarin. Viral load decreased five logs after 4 weeks but it is not negative at end of treatment. Now two months after end of treatment i m having pedal edema. Please suggest.
Mon, 6 May 2013
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General & Family Physician,  's  Response
Hi,
I have gone through your reports fully. I like to say that you have taken the appropriate treatment and follow up. Your worry is the results are not negative and you have pedal edema. Pedal edema is usually associated with your problem. I like to explain certain world statistics about the prognosis.
Out of the 190 patients, 155 (81.6%) achieved End of Treatment Complete Response (EOTCR) whereas 35 (18.4%) were nonresponders (NR). These 155 patients, who showed complete response were followed for six months after the treatment to assess sustained viral response, which was seen in 112 (72.25%) patients whereas 43 (27.7%) were relapsers.
So a periodical consultation + symptomatic treatment is advised.
Best wishes



Hepatitis C virus (HCV) is leading cause of chronic liver diseaseThe relative prevalence of HCV genotypes varies with the geographic area but genotypes 1, 2 and 3 have worldwide distribution.
HCV 3a has been the predominant genotype (causing disease in 62% - 70% patients) in Pakistan based on the last ten years data
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Have Hepatitis C Genotype 3A. Elevated Liver Enzymes. USG Showing Mildly Coarse Liver. Took Ribavarin. Have Pedal Edema. Advice?

Hi, I have gone through your reports fully. I like to say that you have taken the appropriate treatment and follow up. Your worry is the results are not negative and you have pedal edema. Pedal edema is usually associated with your problem. I like to explain certain world statistics about the prognosis. Out of the 190 patients, 155 (81.6%) achieved End of Treatment Complete Response (EOTCR) whereas 35 (18.4%) were nonresponders (NR). These 155 patients, who showed complete response were followed for six months after the treatment to assess sustained viral response, which was seen in 112 (72.25%) patients whereas 43 (27.7%) were relapsers. So a periodical consultation + symptomatic treatment is advised. Best wishes Hepatitis C virus (HCV) is leading cause of chronic liver diseaseThe relative prevalence of HCV genotypes varies with the geographic area but genotypes 1, 2 and 3 have worldwide distribution. HCV 3a has been the predominant genotype (causing disease in 62% - 70% patients) in Pakistan based on the last ten years data