Hello, Welcome to Health Care Magic. Thanks for writing. I am Dr.Saddiq-ul-Abidin. I have read your question completely, i understand your concern and will try to help you in best way possible. Earlobe crease or the Frank s sign has always been a matter of discussion and controversies among researchers, researches have been done on it s association with cardiovascular diseases. What you read on the web is some what true, it has been associated with cardiovascular diseases by doctors. No one can predict presence of Cardio vascular disease if this is found in a patient but that patient should undergo complete work up to check if there is any problem or not. It has been hypothesised that Frank s sign is indicative of cardiovascular disease and/or diabetes. Some studies have described Frank s sign as a marker of cardiovascular disease but not linked to the severity of the condition. In contrast, other studies have rebutted any association between Frank s sign and coronary artery disease in diabetics. There have also been reported cases of Frank s sign assisting in the diagnosis of cerebral infarctions. A link between Frank s sign and premature ageing and the loss of dermal and vascular fibres has also been hypothesized. However, researchers do agree that these creases have no predictive value in Native American Indian and Asian patients END NOTE: In my opinion Frank s sign positive isn t a sure shot indication of somebody having CVS problem but if it is found in some one , the patient should undergo complete work up to rule out any issue if present. I hope this answered your question.If you have more queries I am happy to answer.Otherwise rate and close the discussion Regrads. Dr.Saddiq ul Abidin M.B.B.S(Licensed Family Physician) Resident Medicine.