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Does Zetia Cause Muscle Spasms And Rigidity In The Legs?

Could Zetia cause muscle spasms or cause leg muscles to become rigid after running or other exercise? If so, Will CoQ10 help this? I have been taking Zetia for 6 mo. with no issues until recently. I am 62, in very good health except for cholosterol issues. I cannot take statins because of similar side effects + joint pain. Thank you, Steve Hensel
Wed, 19 Dec 2018
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Internal Medicine Specialist,  's  Response
Hi,

Ezetimibe (Zetia), a lipid-lowering agent can cause muscle toxicity. Myalgia, malaise, muscle tenderness are the most common manifestations. Muscle pain may be related to exercise. Elevated serum CK (>three times baseline), is an important indication of toxicity. You can go for the test, before discontinuing the drug and switch over to other alternatives like Niacin.

Coenzyme Q10 is essentially an antioxidant and has proven useful for only certain specific mitochondrial illnesses (MSA).

Hope I have answered your query. Let me know if I can assist you further.

Regards,
Dr. Tushar Kanti Biswas,
Internal Medicine Specialist
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Does Zetia Cause Muscle Spasms And Rigidity In The Legs?

Hi, Ezetimibe (Zetia), a lipid-lowering agent can cause muscle toxicity. Myalgia, malaise, muscle tenderness are the most common manifestations. Muscle pain may be related to exercise. Elevated serum CK ( three times baseline), is an important indication of toxicity. You can go for the test, before discontinuing the drug and switch over to other alternatives like Niacin. Coenzyme Q10 is essentially an antioxidant and has proven useful for only certain specific mitochondrial illnesses (MSA). Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Tushar Kanti Biswas, Internal Medicine Specialist