Hello! Thank you for asking on HCM! Regarding your concern, i would explain that Losartan and to a smaller degree Spironolacton do affect your blood pressure, in realty they are antihypertensive drugs. When prescribed properly and to needed dosages they are shown effective on managing high blood pressure. Nevertheless, I would like to remember you that there are many different classes and strategies to manage high blood pressure, and depends on your attending physician to choose the right combination. I also advice you to keep monitoring your heart rhythm frequently when using Gilenya, as it may trigger sometimes life-threatening arrhythmia. Hope to have been helpful to you. Greetings! Dr. Iliri