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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Letrozole Cause Weight Gain?

I am HER2 POSITIVE AND COMPLETED CHEMO, HAD A MASTECTOMY AND FOUND THE CANCER HAS SPREAD. MY ONCOLOGIST STARTED ME ON LETROZOLE AND I AM EXPERIENCING SOME OF THE SIDE EFFECTS OF THIS DRUG. IS THE ISSUE OF WEIGHT GAIN SOMETHING THAT CAN BE ADDRESSED BY A MORE STRICT DIET OR IS IT TO BE EXPECTED BECAUSE OF METABOLIC CHANGES.
Tue, 8 May 2018
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General & Family Physician,  's  Response
Hello and Welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.

Letrozole is an anti-estrogen drug that is used for treating postmenopausal women with breast cancer. Weight gain is one of the side effects associated with the use of Letrozole. Weight gain appears to be due to metabolic changes resulting from salt and water retention causing edema.
Losing weight can still be done with careful diet changes and exercise.

Hope I have answered your query. Let me know if I can assist you further.

Regards,      
Dr. Mohammed Taher Ali
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Does Letrozole Cause Weight Gain?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Letrozole is an anti-estrogen drug that is used for treating postmenopausal women with breast cancer. Weight gain is one of the side effects associated with the use of Letrozole. Weight gain appears to be due to metabolic changes resulting from salt and water retention causing edema. Losing weight can still be done with careful diet changes and exercise. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Mohammed Taher Ali