When they say, Do not take non prescription pain medicine longer than required exactly what does that mean? I am worried I may have been damaging my kidneys, as I am now experiencing symptoms of kidney problems. I take non prescription sleeping medication, antihistamines, aleve, and Xanax and two types of antidepressants as well as a medicine for seizures every night, and have done for more than two years. Could this cause my kidneys to shut down?