Hi, Welcome to healthcare magic! It is so unfortunate that you have two uncommon diseases. You are a known case of I.V. but anyone can have a keratoderma. There are a host of types of these diseases, they can be hereditary or acquired and can start all of a sudden. But more commonly the acquired lesions start in areas of frictions and sun/chemical exposure. You should apply the medicine and have regular follow up to the Dermatologist. Simultaneously avoid friction/trauma/sun exposure/chemical exposures if any so that it can be treated to the full extent. I hope this advise would be helpful for you. Still if you have any queries or doubts, please write me back, I would be happy to solve them. Wish you a great health!