Welcome to healthcare magic!
It is so unfortunate that you have two uncommon diseases.
You are a known case of I.V. but anyone can have a keratoderma
There are a host of types of these diseases, they can be hereditary or acquired and can start all of a sudden.
But more commonly the acquired lesions start in areas of frictions and sun/chemical exposure.
You should apply the medicine and have regular follow up to the Dermatologist
Simultaneously avoid friction/trauma/sun exposure/chemical exposures if any so that it can be treated to the full extent.
I hope this advise would be helpful for you.
Still if you have any queries or doubts, please write me back,
I would be happy to solve them.
Wish you a great health!