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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Diagnosed Malignancy. Gave Tyrokinin. Lesions Developed On Face, Head And Hands. Diagnosed Steven Johnson Syndrome And Septicemia. Died. Side Effects Or Malignancy?

Dear Sir,
     My father was 80 year old and he was diagnosed for malignancy in the lungs on 2nd January, 2013 by pleural tap test repeated three times while in first two test this was negative but third time it came positive In IGMC Shimla. Then Dr. referred my father to Radiology Deptt. In Indira Gandhi Medical Collage, Shimla. Then Doctors advised us to go for Chemotherapy but due to body weakness they postponed the chemotherapy then they gave us Tab. TYROKININ 150 OD (Dr. Reddy’s) we started taking this drug on 18.02.2013 and on the morning of 26.02.2013 some pimple like lesions develop on his face and by evening they spread on the face, head and hands. Then we take him the IGMC and Dr. Discontinued the Drug and told us this id side effect of TYROKININ 150 drug and these lesions will subside automatically and advised us to come after seven days. But these lesions turned into painful wound and swelling developed on the face, hands and legs, ulcers developed in the mouth, tongue and food pipe he was unable to swallow in the food even liquids and was not able to even speak. We admitted him in IGMC Shimla on 4th March, 2013 and Dr. reffered us to Skin Department. The Doctors of skin department admitted my father and started their treatment and diagnose. They have given him Augmentin 1.2 gm inj, Direct tab.
Zymogesic ds tab, Muacine gel 200ml, orosore ointment. But on 07.03.2013 he stopped passing urine then Doctors started drip and given him NS & DNS five bottles daily, then his body started retaining waters and swelling developed in the stomach and legs. The Doctors inserted catheter into his urine bladder and found that U. B. was empty. And gave him injections for urination. Then he started urine through catheter upto 600 ml to 1000 ml output. The doctors diagnose the problem as Steven Johnson Syndrome and starting of Septicaemia. After this the Serum Cretinine and blood urea level have started increasing and Doctor told us that it may be case or renal failure but he was not having any problem in the past even 5 days before all the blood reports were OK prior to admitting him into hospital. After that Doctor done his Dialysis on 10.03.2013. The wounds developed in hands and and on face filled with pus. Ultimately he died on 13.03.2013.

Doctor I want to know the reason of his Death wether he died with malignancy or with the side effects of TYROKININ 150 drug or some other reasons as renal failure took place, these wounds/ ulcers. Kindly tell me the reasons or cause of death.

Thanking you.

Yours faithfull,

Er. R.K. Sood

Mon, 27 May 2013
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Oncologist, Radiation 's  Response
Hi,
Sorry to hear about the condition. There may be many causes. Exact cause of death can not be guessed at this moment. Symptoms you have mentioned goes in favor of acute renal failure but what is the underlying pathology can not be stated . Sometimes many drugs show adverse reactions leading to Steven Johnson Syndrome that can not be predicted before. The prescribed drug has low potential of causing this syndrome. Anyway severe infection can also be the cause of multiorgan failure.
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Diagnosed Malignancy. Gave Tyrokinin. Lesions Developed On Face, Head And Hands. Diagnosed Steven Johnson Syndrome And Septicemia. Died. Side Effects Or Malignancy?

Hi, Sorry to hear about the condition. There may be many causes. Exact cause of death can not be guessed at this moment. Symptoms you have mentioned goes in favor of acute renal failure but what is the underlying pathology can not be stated . Sometimes many drugs show adverse reactions leading to Steven Johnson Syndrome that can not be predicted before. The prescribed drug has low potential of causing this syndrome. Anyway severe infection can also be the cause of multiorgan failure.