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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Could Over Dosages Of Benadryl And Morphine Sulfate Be Lethal?

Hello looking for answers with my mothers toxicology report she had 550 nana grams per milliliter of morphine sulfate in her, as well as a level of benedryl that was reported at 1610 mg per liter also her gavapentin levels were at 130 mg per liter. We re all these lethal doses?
Mon, 20 Apr 2015
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General & Family Physician 's  Response
Hi
Thanks for posting your query on HCM.
I appreciate your concern for your mother's toxicology report.

I have gone through the toxicology report given in your query, I am of the opinion that basically all the drugs mentioned work by depressing the functions of the brain producing drowsiness, agitation, fall in BP, decreased breathing, loss of consciousness or coma (if taken in large toxic doses).
Taken together in toxic doses this combination of three drugs can be fatal.
Such patients are required to be treated in ER with resuscitation and maintenance of the airway, and use of specific antidotes like Inj Naloxone for Morphine and Physostigmine for Benadryl.

Hope this answers your query.
Wishing your mother a smooth and quick recovery.
Take care.
A feedback is appreciated.
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Could Over Dosages Of Benadryl And Morphine Sulfate Be Lethal?

Hi Thanks for posting your query on HCM. I appreciate your concern for your mother s toxicology report. I have gone through the toxicology report given in your query, I am of the opinion that basically all the drugs mentioned work by depressing the functions of the brain producing drowsiness, agitation, fall in BP, decreased breathing, loss of consciousness or coma (if taken in large toxic doses). Taken together in toxic doses this combination of three drugs can be fatal. Such patients are required to be treated in ER with resuscitation and maintenance of the airway, and use of specific antidotes like Inj Naloxone for Morphine and Physostigmine for Benadryl. Hope this answers your query. Wishing your mother a smooth and quick recovery. Take care. A feedback is appreciated.