welcome to health care magic
As per your description, your wife probably has "Delusional disorder" in which a person is suspicious of being followed, infected, poisoned etc. Your wife has "jealous" type of delusional disorder in which a partner has suspiciousness of loyality of the other partner that he/she is involved with other person. In such cases, drugs like antipsychotics are required. However these symptoms may also occur in conditions like schizophrenia
. I advise you to visit a psychiatrist
for detailed work up.
Hope it helps
Thanks, leave a review if possible
Dr. Gourav Monga