34yrs. Cerebral palsy . Epilepsy . 24hr care required. Been on tegretol cr and phenobarbitone for years to help control seizures. Neurologist prescribed keppra for 2yrs. No side effects but experienced 1-3 seizures daily. Weened off keppra and started sodium valproate . Within the first week she had experienced sedation, vomitting. Then bloods showed valpro levels low, dose increased. She experienced hypothermia , sedation, vomitting. She lost the ability to swallow food and drink. Bloods showed her phenobarb levels were toxic. Is this common or unheard of for these medications to interacte this way?
Asked On : Fri, 7 Dec 2012