hello, It seems that you are using 5-fluorouracil 5% (efudex) on your face. You have not mentioned for what condition you are using this medicine ( most probably you have been using it for actinic keratosis ). The usual treatment period for face is 2 weeks with avoidance of areas like eyes, nasolabial folds and mouth. An inflammatory reaction is expected, like swelling, oozing and crusting. If a minimal reaction like redness occurs, one can continue for 1-2 weeks. If you initially had seborrheic dermatitis, you should had probably not used this treatment at that time. You still have a mild reaction, therefore, you need to continue it for another 1-2 week. At this time, you have two choices: 1. If You are too uncomfortable with the whole thing, stop everything, apply a mild steroid twice a day (fluticasone etc) for a week. Get you seborrheic dermatitis controlled and after that do your efudex regime again 2. In case, you don t want to do this whole procedure again, reduce the dose of efudex like 2%. continue for another 10 days. Alongwith it, start using same steroid cream and continue for one week after stopping the whole regime of efudex. Thanks Dr Jyoti Gupta