Hi Thanks for contacting HCM Here are the side effects of Methotrexate- Methotrexate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: joint or muscle pain reddened eyes swollen gums hair loss Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment: vomiting blurred vision or sudden loss of vision sudden fever, severe headache, and stiff neck seizures confusion or memory loss weakness or difficulty moving one or both sides of the body difficulty walking or unsteady walking loss of consciousness impaired speech decreased urination swelling of the face, arms, hands, feet, ankles, or lower legs hives itching skin rash difficulty breathing or swallowing Methotrexate may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, contact your doctor.