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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Hydrochlorothiazide Be Taken While Suffering From Lupus Cerebritis?

I have Lupus cerebritis. It obviously went after my brain. The lupus is now well under control for about 3 years now blood tests show. Recently my MD prescribed Hydrochlorothiazide for my BP AND it’s worked great. But I’ve read hydrochloride can activate my lupus. Not good for someone who recovered from brain lupus. Is this true?
Wed, 10 Jan 2018
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's  Response
I appreciate that you have done your bit of homework on the medication.. Yes your worry is genuine.
Hydrochlorthiazide does come with a warning label that it may exacerbate systemic lupus erythematosis. It is also documented as one of the causal agents of drug induced lupus.
Now since that is what you already know, let's think of a practical solution for your hypertension.
As you already have lupus, I assume that there would be some amount of lupus nephritis( kidneys being affected because of lupus). You can check it by getting your 24 hr urine protein quantified. In that scenario, the best drug in my opinion would be an ACE inhibitor.. it shal kill both your enemies with one sword.
The other available and safe option for you is nifedipine..
I would recommend you to discuss the same with your treating physician.. Do feel free to discuss if you have any further queries
Thanks
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Can Hydrochlorothiazide Be Taken While Suffering From Lupus Cerebritis?

I appreciate that you have done your bit of homework on the medication.. Yes your worry is genuine. Hydrochlorthiazide does come with a warning label that it may exacerbate systemic lupus erythematosis. It is also documented as one of the causal agents of drug induced lupus. Now since that is what you already know, let s think of a practical solution for your hypertension. As you already have lupus, I assume that there would be some amount of lupus nephritis( kidneys being affected because of lupus). You can check it by getting your 24 hr urine protein quantified. In that scenario, the best drug in my opinion would be an ACE inhibitor.. it shal kill both your enemies with one sword. The other available and safe option for you is nifedipine.. I would recommend you to discuss the same with your treating physician.. Do feel free to discuss if you have any further queries Thanks