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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Blister Rash On Limbs, Back, Tired, Achy. Prescribed Prednisone, Relief Temporary. Blood Test Done. Lupus?

Hello, I have been dealing with a rash on hands, legs, back, arms and now bottom of my feet for the last 7yrs. I was prescribed 2 steroid creams and they have not worked for 7yrs. I asked my doctor to test me for lupus and she put me on prednisone which I was on 2 times before and it makes the rash go away for a little while. I was sent to a skin specialist 5yrs ago and they gave me the same 2 creams and still nothing works. I do have a copy of my blood test in which it says --- SEDWEST is 42, CRP is 2.5, RF is <4 , ANA is positive, ANAT1 is 1:320 and ANAP1 homogenous. So I guess my question is do I have lupus? my rash starts out like a blister and then itches then turns yellowish green then brown. I do not have a blister rash on my face but, I do have redness on cheeks and nose. sometimes I do run a low grade fever, tired, achy and my eyes are always dry.
Thu, 14 Nov 2013
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General & Family Physician 's  Response
hello there!
The classic presentation of a triad of fever, joint pain, and rash all points towards the lupus. So dpes the positive homogeneous ANA
How many of these complaints you have?
Constitutional (eg, fatigue, fever, arthralgia, weight changes)
Musculoskeletal (eg, arthralgia, arthropathy, myalgia, frank arthritis, avascular necrosis)
Dermatologic (eg, malar rash, photosensitivity, discoid lupus)
Renal (eg, acute or chronic renal failure, acute nephritic disease)
Neuropsychiatric (eg, seizure, psychosis)
Pulmonary (eg, pleurisy, pleural effusion, pneumonitis, pulmonary hypertension, interstitial lung disease)
Gastrointestinal (eg, nausea, dyspepsia, abdominal pain)
Cardiac (eg, pericarditis, myocarditis)
Hematologic (eg, cytopenias such as leukopenia, lymphopenia, anemia, or thrombocytopenia)

the more you have the more the Odds for lupus.

As your ANA is positive Homogeneous It has pointed lupus further but ANA is not that specific.
You need to do Anti Double stranded DNA and Anti Smith antibodies to confirm.
You need a detailed workup for SLE, Anticardiolipin, Lupus Anticoagulant

Complete blood count (CBC) with differential
Serum creatinine
Urinalysis with microscopy
Erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP)
Complement levels
Liver function tests
Creatine kinase assay
Spot protein/spot creatinine ratio
Brain MR scans
joint effusions arthrocentesis

and last but not the least RENAL BIOPSY to Assess the severity of lupus nephritis.

You need a whole panel of Rheumatologist
Infectious disease specialist
Neurologist
Pulmonologist
Cardiologist
Gastroenterologist
Nephrologist
Dermatologist
Hematologist
High-risk obstetrician( if female with plan to pregnancy)

A simple steroids wont help.

So what are you waiting for. Grab your coat and see the nearby rheumatologist to start it. You need to control the progression and care for your vital organs if you need to survive.

Take care of yourself

Regards
Dr Khan
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Blister Rash On Limbs, Back, Tired, Achy. Prescribed Prednisone, Relief Temporary. Blood Test Done. Lupus?

hello there! The classic presentation of a triad of fever, joint pain, and rash all points towards the lupus. So dpes the positive homogeneous ANA How many of these complaints you have? Constitutional (eg, fatigue, fever, arthralgia, weight changes) Musculoskeletal (eg, arthralgia, arthropathy, myalgia, frank arthritis, avascular necrosis) Dermatologic (eg, malar rash, photosensitivity, discoid lupus) Renal (eg, acute or chronic renal failure, acute nephritic disease) Neuropsychiatric (eg, seizure, psychosis) Pulmonary (eg, pleurisy, pleural effusion, pneumonitis, pulmonary hypertension, interstitial lung disease) Gastrointestinal (eg, nausea, dyspepsia, abdominal pain) Cardiac (eg, pericarditis, myocarditis) Hematologic (eg, cytopenias such as leukopenia, lymphopenia, anemia, or thrombocytopenia) the more you have the more the Odds for lupus. As your ANA is positive Homogeneous It has pointed lupus further but ANA is not that specific. You need to do Anti Double stranded DNA and Anti Smith antibodies to confirm. You need a detailed workup for SLE, Anticardiolipin, Lupus Anticoagulant Complete blood count (CBC) with differential Serum creatinine Urinalysis with microscopy Erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) Complement levels Liver function tests Creatine kinase assay Spot protein/spot creatinine ratio Brain MR scans joint effusions arthrocentesis and last but not the least RENAL BIOPSY to Assess the severity of lupus nephritis. You need a whole panel of Rheumatologist Infectious disease specialist Neurologist Pulmonologist Cardiologist Gastroenterologist Nephrologist Dermatologist Hematologist High-risk obstetrician( if female with plan to pregnancy) A simple steroids wont help. So what are you waiting for. Grab your coat and see the nearby rheumatologist to start it. You need to control the progression and care for your vital organs if you need to survive. Take care of yourself Regards Dr Khan