Hello. Thank you for asking at HCM. I went through your history and understand your concern about lifelong immunotherapy. Decision regarding duration of immunotherapy (shots) is very much individualized. Were I treating you, I would like to discuss a few important concerns with you before planning discontinuation. 1. The most important thing - you had a life-threatening reaction to vespid so this is a matter of life and death. Lifelong continuation of immunotherapy is the safest approach. 2. I would suggest you to have allergy skin testing to vespid venom as well as serum specific IgE to vespid venom after 5 years of starting shots. If both these have turned negative, I would consider it safe to discontinue shots at that time provided your environment, lifestyle and occupation does not put you at a high-risk of having vespid sting. Hope this will be helpful to you. Wish you the best of the health. Regards.