Hi Thanks for your query. I appreciate your concern for the safety of Cremaffin plus on prolonged use. Cremaffin plus (liquid paraffin,magnesium hydroxide and sodium picosulfate) is a laxative used in cases of constipation. Long term use or unnecessary use of this medicine can cause a few side effects:- 1. Habit forming 2. Soiling of the undergarments and anal irritation, 3. May reduce the absorption of fat soluble vitamins that are A,D,E and K, (as a result you can suffer from deficiency of any of these), 4. Aspiration in to the lungs causing inflammation 5. Abdominal pain due to enlarged lymphatics For the weakness and the constipation you are advised to consult a surgeon for further evaluation may be you need a colonoscopy to rule out the commons causes of constipation. Hope I have answered your query. Rate this answer, if you are convinced.