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Acute Myelogenous Leukemia-M2, chemotherapy taken,platelet drop? survival rate?

sir my name is for AML -M2 for my brother (Age 36) He is suffering AML-M2 Since 4 Oct-2011.he has gone through treatmens like induction chemo and High Dose chemo for 3 Cycle and sent home and after 15 days checked bonemarow biopsy Result is Abnormal Cell Nill After One months He has checked CBC 1) Hemoglobin :- 11.5%, WBC :- 6,000 3) Platelates :- 0000 but platelates is dropped. what is Reason. or What is Percentage of survial rate. please help me in this regards
Asked On : Sun, 6 May 2012
Answers:  4 Views:  441
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General & Family Physician 's  Response
Hello
Persons with this type of cancer have abnormal cells inside their bone marrow. The cells grow very fast, and replace healthy blood cells. The bone marrow, which helps the body fight infections, eventually stops working correctly. Persons with AML become more prone to infections and have an increased risk for bleeding as the numbers of healthy blood cells decrease.

When the signs and symptoms of AML go away, you are said to be in remission. Complete remission occurs in most patients.

With treatment, younger patients with AML tend to do better than those who develop the disease at an older age. The 5-year survival rate is much lower in older adults than younger persons. Experts say this is partly due to the fact that the body of a younger person can better tolerate strong chemotherapy medicines.

If the cancer does not come back (relapse) within 5 years of the diagnosis, you are considered permanently cured.

Complications of AML and cancer treatment include severe infections and life-threatening bleeding. Sometimes, the cancer comes back (relapses) after treatment.
Thanks and best of luck to your brother.
Answered: Sun, 6 May 2012
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General & Family Physician Dr. Pavan Kumar Gupta's  Response
Hello
Persons with this type of cancer have abnormal cells inside their bone marrow. The cells grow very fast, and replace healthy blood cells. The bone marrow, which helps the body fight infections, eventually stops working correctly. Persons with AML become more prone to infections and have an increased risk for bleeding as the numbers of healthy blood cells decrease.

When the signs and symptoms of AML go away, you are said to be in remission. Complete remission occurs in most patients.

With treatment, younger patients with AML tend to do better than those who develop the disease at an older age. The 5-year survival rate is much lower in older adults than younger persons. Experts say this is partly due to the fact that the body of a younger person can better tolerate strong chemotherapy medicines.

If the cancer does not come back (relapse) within 5 years of the diagnosis, you are considered permanently cured.

Complications of AML and cancer treatment include severe infections and life-threatening bleeding. Sometimes, the cancer comes back (relapses) after treatment.
Thanks and best of luck to your brother.
Answered: Sun, 6 May 2012
I find this answer helpful
General & Family Physician Dr. Chandra Shekhar Sharma's  Response
Hi shailesh,
Chemotherapeutic agents are cytotoxic, and target actively dividing cells. In Bone marrow, digestive tract & hair follicles cells divide rapidly under normal circumstances. Due to chemotherapy megakaryocytes which produce platelets in the bone marrow are destroyed, thus reduce the platelet count. Acute Myeloid Leukemia is a curable disease. The prognosis in a particular case depends upon number of factors, most important of which is cytogenetics.
With good wishes,
Answered: Sun, 6 May 2012
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Pediatrician Dr. Suryakanta Baraha's  Response
hi shailesh,
welcome to hcm
thanks for the query
platelets decrease in AML because the actively deviding tumor cells replace the platelet precursor cells in bone marrow.
in younger age there is chance of good cure rate.cure rate depends on also on your cytogenetics,your blood lactate dehydrogenase level. have you done your cytogenetic study?m2 subtype has favorable prognosis.so continue your chemo course and get cured soon.take care
Answered: Mon, 7 May 2012
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