For that i will need your history and blood pressure status kindly come up with complete history in follow up question or through direct message at my profile thanks.

Regards.

Dr.Muhammad Ahmad

Resident Cardiology.

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Brief Answer:
Only concern is hypotension.

Detailed Answer:
Hi,

Thanks for writing back,

It's a pleasure to know that you are a doctor yourself, it will be easy for you to understand how we adjust the dose.

Trandolopril has half life of 10 hours and lisinopril has half life of about 13 hours, but trandolopril is more potent, so we have to use trandolopril in lesser amounts but in BiD dose.

I would tell my patients that, When you are going to switch to lisinopril I would suggest you to start with 5mg BD , taking them 12 hours apart.

Keep checking your blood pressure thrice a day if it stays well well under limits then you won't have to worry about anything,

Here I want to mention that you are taking diuretic so keep a good check at your BP in starting days like, specially in first two hours of tablet if blood pressure stays above 90/50 then you can continue, with time you will learn about your body habit , how it responds to this particular medicine. If you go to hypotension you might want to reduce dose of lisinopril, to 2.5mg but at the moment you can start with a 5mg BiD.

This was my opinion how i would start Zestril(lisinopril) to my patient, taking them off trandolopril.

You can dicuss with your doctor and start the dose. I believe there shouldn't be any big issues in this. Only thing you have to take care about is hypotension, and being a doctor yourself i believe you can well take care of it.

Stay blessed.

Wish you the best of health.

Regards.

Dr. Muhammad Ahmad.

Resident Cardiology.

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