Brief Answer:
There is decreased kidney function due to obstruction of flow of urine.

Detailed Answer:
Hi XXXXXX,
Thanks for writing in to us.

I have read through your query in detail.
Having worked in a cancer institute for few years and have seen many patients of cancer cervix with conditions affecting the kidneys and bladder. I guess that you have got radical hysterectomy and radiation for a possible diagnosis of cervical cancer. Presently radiation is given over a small field and it is unlikely that your radiation included the kidneys. However, it is possible that the field of radiation was over the pelvis and might have included the urinary bladder and lower end of ureters or bladder outlet. This can cause strictures in the ureters or urethra causing some amount of obstruction to the flow of urine resulting in back flow of urine to the kidneys causing irreversible kidney damage that includes scarring and thinning of kidney cortical parenchyma.

From the values provided creatinine is 97 and eGFR is 60 then it is under chronic kidney disease stage 3 A. You need to consult a nephrologist and be under constant supervision to salvage the kidney functions and slow the progression of kidney disease.

Hope this answers your question. Please feel free to correct any oversight in my interpretation of your problems and discuss them in detail as per your requirements.

Hope your query is answered.
Do write back if you have any doubts.

Regards,
Dr.Vivek

---

Brief Answer:
Kidney injury does not cause hormone related increase in weight

Detailed Answer:
Hi XXXXXX,
Thanks for writing back with an update.

I appreciate your information and I was of the opinion that you have obstruction to flow of urine as you had mentioned ultrasound for kidneys due to lack of voiding in your previous message.

There are however other causes of kidney cortical parenchymal thinning other than obstruction to flow of urine. This can also cause kidney scarring and decline in kidney functions as seen by slightly increased serum creatinine and decreased eGFR.

There is no direct relation between an injury to the kidneys and increase in weight due to hormone problems. On the other hand, obesity is linked to diabetes and hypertension, both of which can cause kidney diseases if not controlled.

Your kidney condition needs to be investigated and if required, a biopsy will have to be done to know the changes in kidney cells which can confirm the exact condition. You might also need to get urinary protein excretion tests. Serum creatinine levels are to be monitored regularly.

Hope your query is answered.
Do write back if you have any doubts.

Regards,
Dr.Vivek

---