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What Does Crohn's Disease With Elevated Alk Phos Level Indicate?

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Posted on Wed, 9 Apr 2014
Question: Hello- I am a 31yo female with Hx of crohn's disease who has been having intermittent RUQ abdominal pain over the last year. I first get R shoulder pain for 1-2 days before the belly pain begins. Originally it was thought to be my gallbladder. I had an ultrasound and nuclear testing done which came back normal. I have been to the ED for when the pain begins numerous times as it affects my daily life when I get it. They have done blood work, X-ray and CT-scans which were all normal. I was told it was my crohn's and to see my GI. I made my GI aware when he was performing a routine colonoscopy and he stated everything was normal except for having crohn's which is in my RLQ. Recently I have started to see a new provider and had blood work done. My Alk Phos level was 126 (normal range was to 122). My Triglyerides were slightly elevated (I think they were 155), my iron was slightly low at 52, my vitamin D was low at 14 and my vitamin B12 was low at 138. The low vitamins are being addressed with taking oral vitamins and B12 injections. My concern is with the elevated alk Phos level. Is this a source for my RUQ pain? On palpitation my provider said my liver did not feel enlarged and suggested I get another CT scan done of my liver. The last one I had was around Oct, 2013. Is this necessary again? I'm just becoming frustrated as this pain still keeps coming and going but no one can figure out the cause. Nothing makes it better, nothing makes it worse (including what I'm eating). Now when I get the pain I don't go to the doctor to be seen because I feel as if they're just going to tell me nothing is wrong again and I'm tired of hearing that or made to feel like I am drug seeking. Any thoughts will be greatly appreciated!
doctor
Answered by Dr. Enrique Molina (39 minutes later)
Brief Answer: further liver testing Detailed Answer: Hi, i am sorry that you are in so much discomfort without an obvious source. The fact that you have Crohn's and an elevated alk phos makes me think right off the bat about Primary Sclerosing Cholangitis. An ultrasound would not pick this up, and a CT scan may, but it's not the best test. I would suggest an "MRCP" (special type of MRI) to take a good image of the liver and bile ducts. However keep in mind that your alk phos was very minimally elevated, and it could just be a fluctuation of your labs. I would suggest you getting checked for all types of liver diseases related to Crohn's such as PSC mentioned above, also autoimmune hepatitis (by blood testing). Pain not necessarily is from the liver, even though it is in the RUQ area. People with Crohn's can become "hypersensitive", and it is common to get "irritable bowel syndrome" as well. There are many anti-spasmodics and medications for neuropathic pain that can be tried if nothing is found on further testing. Another option is what is called "biliary dyskinesia", where the gallbladder does not function properly, however looks normal on CT or ultrasound. A functional study of the gallbladder can be performed to evaluate for this (test is called Hepatobiliary scan with CCK injection). Removing the gallbladder would solve this particular problem. Hope that helps. let me know if you have any further questions or concerns
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Follow up: Dr. Enrique Molina (9 hours later)
The hepatobiliary scan w/ CCK injection, is that a nuclear test? I know I had a test that they injected me with nuclear material and they had to do a scan about every 15min for an hour or so. The scan i had was normal. Thank you for all your help .
doctor
Answered by Dr. Enrique Molina (10 hours later)
Brief Answer: yes Detailed Answer: yes it is a nuclear medicine test, they do inject contrast, and it could be done with or without CCK. CCK, which is a hormone that stimulates the gallbladder contractions, is not routinely given unless the ordering physician asks for it. So i can't tell by what you are telling me if you indeed had CCK injection or not, however it does sound like you did at least have the hepatobiliary scan.
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Enrique Molina

Internal Medicine Specialist

Practicing since :2004

Answered : 364 Questions

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What Does Crohn's Disease With Elevated Alk Phos Level Indicate?

Brief Answer: further liver testing Detailed Answer: Hi, i am sorry that you are in so much discomfort without an obvious source. The fact that you have Crohn's and an elevated alk phos makes me think right off the bat about Primary Sclerosing Cholangitis. An ultrasound would not pick this up, and a CT scan may, but it's not the best test. I would suggest an "MRCP" (special type of MRI) to take a good image of the liver and bile ducts. However keep in mind that your alk phos was very minimally elevated, and it could just be a fluctuation of your labs. I would suggest you getting checked for all types of liver diseases related to Crohn's such as PSC mentioned above, also autoimmune hepatitis (by blood testing). Pain not necessarily is from the liver, even though it is in the RUQ area. People with Crohn's can become "hypersensitive", and it is common to get "irritable bowel syndrome" as well. There are many anti-spasmodics and medications for neuropathic pain that can be tried if nothing is found on further testing. Another option is what is called "biliary dyskinesia", where the gallbladder does not function properly, however looks normal on CT or ultrasound. A functional study of the gallbladder can be performed to evaluate for this (test is called Hepatobiliary scan with CCK injection). Removing the gallbladder would solve this particular problem. Hope that helps. let me know if you have any further questions or concerns