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What Do My Lab Test Results Indicate?
Question: Early August 2015 I was hospitalized with an SMV occlusion and portal vein thrombus.
Over the past 10 months my ALT and AST labs have escalated while Alkaline Phosphate levels remained well within the normal range.
AST 37-75
ALT 51-117
Hemoglobin 14.03-17.4
Hematocrit 42-50.2
Medications:
5mg warfarin
120mg Cardizem LA (afib)
Lanzoprazole
L-Lysine supplement
Multi-vitamin
As a result of my changing labs, my hematologist has scheduled a Jak 2 Exon 12 Mutation Dx test and have a pending appointment with a heptologist.
Can you help me understanding what they maybe looking for and what it means?
Thank you!
Over the past 10 months my ALT and AST labs have escalated while Alkaline Phosphate levels remained well within the normal range.
AST 37-75
ALT 51-117
Hemoglobin 14.03-17.4
Hematocrit 42-50.2
Medications:
5mg warfarin
120mg Cardizem LA (afib)
Lanzoprazole
L-Lysine supplement
Multi-vitamin
As a result of my changing labs, my hematologist has scheduled a Jak 2 Exon 12 Mutation Dx test and have a pending appointment with a heptologist.
Can you help me understanding what they maybe looking for and what it means?
Thank you!
Brief Answer:
looking for myeloproliferative diseases
Detailed Answer:
Hi
Thanks for your query.
Considering your history of unprovoked thrombus and rising hemoglobin and hematocrit, your hematologist has suspected myeloproliferative disorder. It is a group of diseases where the bone marrow becomes overactive and produces more blood cells (red, white or platelets).
Jak mutation is a genetic abnormality found in some of these disorders. Not only will it confirm the diagnosis but also will suggest specific treatment.
Liver function is difficult to explain by this, that's why a hepatologist opinion has been sought. A liver ultrasound and viral screen may be done for it.
Hope this helps.
Regards
looking for myeloproliferative diseases
Detailed Answer:
Hi
Thanks for your query.
Considering your history of unprovoked thrombus and rising hemoglobin and hematocrit, your hematologist has suspected myeloproliferative disorder. It is a group of diseases where the bone marrow becomes overactive and produces more blood cells (red, white or platelets).
Jak mutation is a genetic abnormality found in some of these disorders. Not only will it confirm the diagnosis but also will suggest specific treatment.
Liver function is difficult to explain by this, that's why a hepatologist opinion has been sought. A liver ultrasound and viral screen may be done for it.
Hope this helps.
Regards
Above answer was peer-reviewed by :
Dr. Yogesh D
Is it normal for the elevation in labs to begin after clotting events 10 years apart?
I've also read that absent a finding of JAK 2 mutation, that the SMV/PV thrombus could potentially be causing PV hypertension. I assume that's a possibility without a myeloproliferative disease?
Thank you!
I've also read that absent a finding of JAK 2 mutation, that the SMV/PV thrombus could potentially be causing PV hypertension. I assume that's a possibility without a myeloproliferative disease?
Thank you!
Brief Answer:
it can cause portal hypertension
Detailed Answer:
In your main query you mentioned 10 months while in followup it is 10 years. I am not sure which one is correct. 10 months is definitely possible.
Portal vein or smv thrombosis can definitely cause portal hypertension, with or without myeloproliferative disorders.
it can cause portal hypertension
Detailed Answer:
In your main query you mentioned 10 months while in followup it is 10 years. I am not sure which one is correct. 10 months is definitely possible.
Portal vein or smv thrombosis can definitely cause portal hypertension, with or without myeloproliferative disorders.
Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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