Brief Answer:
No, not normal

Detailed Answer:
Cannot say in your particular case, I can only say that all the biopsies I've seen or heard about have been dime sized or smaller. They hurt about as much as a scraped knee (or less).

Any time an area of skin is broken it is at risk of infection. Areas that rub, are moist, have folds, that smell are much much more likely to have germs and have infections.

So, increasing pain after a procedure especially more than a day later and still increasing implies infection. Other general reasons to suspect an infection are outlined above:
area should not have much damage, it doesn't get that painful.
area should be healing
area is highly prone to infection
etc.
Infections need immediate treatment.

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