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What Causes Elevated Liver Enzyme Levels?

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Posted on Thu, 3 Nov 2016
Question: Liver enzymes moderately high AST and ALT what problems do they indicate
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Answered by Dr. Michelle Gibson James (25 minutes later)
Brief Answer:
non alcoholic liver disease is one of the more common causes

Detailed Answer:
HI, thanks for using healthcare magic

The more common causes of increases in AST and ALT can be due to : (1) non alcoholic fatty liver disease- this is one of the most common causes as present

It is due to build up of fat in the liver which can then go on to cause inflammation and damage to the liver if it is allowed to progress

Treated with diet changes, activity and medications

(2)alcohol- persistent use of a lot of alcohol causes damage

(3)side effect of medications eg statins for cholesterol. This does not happen to all persons who use the statins, only some

(4)infection- hepatitis is another cause of abnormal liver enzymes

(5)hemochromatosis- iron is deposited in the liver

Your doctor may suggest an ultrasound or CT of the abdomen to take a look at the liver.
Additional bloods, if not already done, may also be requested to determine the cause eg complete blood count, cholesterol levels, iron and the hepatitis viruses

I hope this helps, feel free to ask any other questions
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Michelle Gibson James

General & Family Physician

Practicing since :2001

Answered : 16808 Questions

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What Causes Elevated Liver Enzyme Levels?

Brief Answer: non alcoholic liver disease is one of the more common causes Detailed Answer: HI, thanks for using healthcare magic The more common causes of increases in AST and ALT can be due to : (1) non alcoholic fatty liver disease- this is one of the most common causes as present It is due to build up of fat in the liver which can then go on to cause inflammation and damage to the liver if it is allowed to progress Treated with diet changes, activity and medications (2)alcohol- persistent use of a lot of alcohol causes damage (3)side effect of medications eg statins for cholesterol. This does not happen to all persons who use the statins, only some (4)infection- hepatitis is another cause of abnormal liver enzymes (5)hemochromatosis- iron is deposited in the liver Your doctor may suggest an ultrasound or CT of the abdomen to take a look at the liver. Additional bloods, if not already done, may also be requested to determine the cause eg complete blood count, cholesterol levels, iron and the hepatitis viruses I hope this helps, feel free to ask any other questions