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What Causes Elevated CPK Levels?

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Posted on Mon, 15 Dec 2014
Question: What could possibly be the cause of elevated CPK levels when:
1. There has been NO trauma.
2. Light exercise and NO protein powder drinks.
3. No statin medicines.

Reason for ADH hormone deficiencies? Mine is below 1.

I am very healthy in terms of emotional/mental, eat 90% organic and regular exercise.

Thank you
doctor
Answered by Dr. Shehzad Topiwala (1 hour later)
Brief Answer:
CPK ADH

Detailed Answer:
CPK can be elevated in several other situations such as

1 Under active thyroid (hypothyroidism)

2 Cushings syndrome (excess steroid hormone levels in the body)

3 Motor neuron disease

4 In certain ethnicities such as XXXXXXX Americans

5 Certain manual labor occupations – This is particularly true among those jobs that involve vigorous upper extremity use or constrained postures

6 Idiopathic – No explanation is found despite thorough investigation, including muscle biopsy, and weakness does not develop during subsequent follow-up

7 Macro CK – Macro CK usually occurs in healthy individuals without evidence of muscle disease

Regarding your second question: reason for ADH deficiency.

If there is significant damage to the posterior pituitary which is the source of ADH, then ADH levels will be low. Reasons for damage can be trauma or surgery to the pituitary or hypothalamus area of the brain, or a tumor/ infection in that area.

But endocrinology is a complex science and experts have realized that unless there are signs and symptoms suggestive of ADH deficiency, it is not advisable to check the blood levels. This is particularly important because not all labs can process the ADH sample correctly. It requires finesses and correct storage. Besides, when there is true ADH deficiency a syndrome called Diabetes Insipidus develops in which the affected individual passes a lot of urine and is continuously thirsty. Often the blood sodium levels rise too.


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Shehzad Topiwala (3 days later)
Thank you Dr. Topiwala for your very detailed response. I have seen a neurologist, Endocrinologist, a few Internist's and they seem to write me off for the most part, due to the fact that in person, I look 100% healthy. So I was quite pleased when the CPK levels were found although at the time I had no idea the complexity of this enzyme. I am taking very good vitamins. My CPK last year was around 800 tested 3 times within a 1 month time frame. This year, within 2 months time, they are 1100, 1400, 2200, 900, last test 580. I made certain that I did not exercise at least 2 days prior to the test. May I ask, is there any study done or is there a chance that a psychological matter could be associated with elevated CPK? I don't know where to turn. I have done every blood test under the sun. My ADH hormone was below 1 so that is why I asked about that. My liver enzymes are a bit elevated but nothing to be alarmed about. I have done endless research and do not believe I have any type of myositis disease. My symptoms daily consist of: fatigue, brain fog and upper back pain. I am an optimistic person, however, with these continuing symptoms, I have become blue and discouraged. Thank you for your help. Best!
doctor
Answered by Dr. Shehzad Topiwala (24 hours later)
Brief Answer:
Follow up

Detailed Answer:
I suggest you see a Rheumatologist to evaluate potential causes of CPK elevations.

CPK and ADH have no connection.

Sometimes nutritional and vitamin supplements which are not regulated as well as prescription medications can be harmful especially when inadvertently consumed in high quantities.

Check with your doctor which ones are really necessary
Note: For more information on hormonal imbalance symptoms or unmanaged diabetes with other comorbid conditions, get back to us & Consult with an Endocrinologist. Click here to book an appointment.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Shehzad Topiwala

Endocrinologist

Practicing since :2001

Answered : 1663 Questions

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What Causes Elevated CPK Levels?

Brief Answer: CPK ADH Detailed Answer: CPK can be elevated in several other situations such as 1 Under active thyroid (hypothyroidism) 2 Cushings syndrome (excess steroid hormone levels in the body) 3 Motor neuron disease 4 In certain ethnicities such as XXXXXXX Americans 5 Certain manual labor occupations – This is particularly true among those jobs that involve vigorous upper extremity use or constrained postures 6 Idiopathic – No explanation is found despite thorough investigation, including muscle biopsy, and weakness does not develop during subsequent follow-up 7 Macro CK – Macro CK usually occurs in healthy individuals without evidence of muscle disease Regarding your second question: reason for ADH deficiency. If there is significant damage to the posterior pituitary which is the source of ADH, then ADH levels will be low. Reasons for damage can be trauma or surgery to the pituitary or hypothalamus area of the brain, or a tumor/ infection in that area. But endocrinology is a complex science and experts have realized that unless there are signs and symptoms suggestive of ADH deficiency, it is not advisable to check the blood levels. This is particularly important because not all labs can process the ADH sample correctly. It requires finesses and correct storage. Besides, when there is true ADH deficiency a syndrome called Diabetes Insipidus develops in which the affected individual passes a lot of urine and is continuously thirsty. Often the blood sodium levels rise too.