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What Causes Depression Despite Taking Wellbutrin And Prozac?

Posted on Wed, 26 Apr 2017

Question: I have been diagnosed with severe depression. I take Wellbutrin, Prozac, and Abilify. I feel better, but have lingering feelings of depression. My dr said that I have a resistance to medications, I was wondering if remeron (Mirtazapine) would be helpful to add to my prescriptions.

Or is there another medication that you would suggest?

Answered by Dr. Dr. Ashok Kumar Choudhary (30 minutes later)

Brief Answer:
Please share the following details

Detailed Answer:
Hello,
Thanks for using Healthcaremagic.

I read your query and understand your concerns about ill responsiveness of depression.

I request you to share following details.

1. Dosage and duration of each medication
2 Your current symptoms
3. Your body weight andheight
4. Do you have any physical illness, provide details if any
5. Medications used the past and their response

I look forward to get above details to guide you appropriately.

Thanks and regards.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Dr. Ashok Kumar Choudhary (2 hours later)

I take Abilify 5mg, Prozac 30mg, Wellbutrin 450mg, Topamax 75mg. All daily.
I have feelings of depression: lack of energy, sadness, my biggest complaints.
My weight is 123lb and my height is 5' 1"
I have hypothyroidism which I take Unithroid for.
Past meds:
Lexapro
Prozac
Abilify
Wellbutrin
Topamax
Effexor
Amitriptyline
Neorontin
Cymbolta
Lamictal
Viibryd
Lithium
Prozac & Lithium together
Prozac & Zyprexa together
Adderal
Brintellex
Remeron
Paxil
Rexulti
Rexulti, Lithium, Paxil together
Prozac, Wellbutrin, Topamax, Rexulti together
Inderal

Answered by Dr. Dr. Ashok Kumar Choudhary (15 minutes later)

Brief Answer:
Follow up

Detailed Answer:
Dear XXXX,
Thanks for follow up and proving required details.

There is no harm in adding mirtazapine to current prescription in dose range of 15-30 mg per day to augment antidepressant effect which could be quite helpful for you.

I am also of the opinion that increment in dose of Abilify should be considered in dose range of 10 mg per day from current 5 mg per day. This recommendation is based on the fact that low dose abilify augments action of antidepressants and I think 5 mg is proving insufficient for this purpose.

I hope this helps you.
If you have any further query, I would be glad to help you.
If not, you may close the discussion and if possible you may rate the answer for my future patients.
In future if you wish to contact me directly, you can use the below mentioned link:
http://doctor.healthcaremagic.com/doctors/dr-ashok-kumar/67386
Thanks and regards.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Dr. Ashok Kumar Choudhary (1 hour later)

Thank you very much. How much Tyrosine would you recommend?

Answered by Dr. Dr. Ashok Kumar Choudhary (1 hour later)

Brief Answer:
Tyrosine have no role

Detailed Answer:
Hello,
Thanks for follow up.

I am not sure why you are asking for tyrosine dose as it does not have any direct role in depression.

If it is just typo and you mean ABILIFY by tyrosine, I will recommend 10 mg of abilify instead of 5 mg which you are taking today.

I hope this clarifies.
Thanks and regards.

Note: For further guidance on mental health, Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar