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What Causes IBS While On Ramipril, Nexium, Sinemet And Bystolic?

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Posted on Wed, 15 Mar 2017
Question: I have had celiac disease for 20 years. In the last year I was prescribed medications containing gluten . Unbeknownst to or my doctors. This despite fact I always alert doctors to the celiac disease. These were ramipril, Nexium, Senemet, bystolic. I had immediate reactions to the last three-- took ramipril for about a month before reaction. My question: prior to taking these drugs I had no lactose intolerance or IBS. Now I seem to have both. Can ingestion of these sorts of drugs cause these effects? My doctors did not know that there was gluten in these drugs. Now I do and and carry the list of of gluten containiing drugs from the Internet on my phone. The problem is IBS is much harder to cope with than a gluten free diet and my quality of life has deteriorated.
doctor
Answered by Dr. Ramesh Kumar (21 hours later)
Brief Answer:
Side effect of Sinemet

Detailed Answer:
Hi,
Thanks for choosing HealthcareMagic for your query.
Have gone through all your details.

Sinemet contains Carbidopa and Levodopa, A very common side effect of (Carbidopa-Levodopa) is loose stools. This drug causes an upset stomach, there by irritating the gastrointestinal tract and digestive system. Irritation of the gastrointestinal tract may expedite the shuttling of food through the digestive tract and lead to frequent bowel movements with loose stools. So basically its not exactly irritable bowel syndrome, But as the drug is constantly irritating your gastro-intestinal tract so it causes improper digestion of food with increased motility leading to frequent bowel moments.
One way to potentially decrease likelihood of G.i irritation is to take Sinemet along with food or after a big meal; this may reduce gastrointestinal irritation as caused by the medication.
However if its detoriating the quality of life then i would advice you to take Clidinium. Don't take imodium;Imodium contains loperamide and is not a safe drug and should be avoided. However Clidinium is very safe and is frequently used to control irritable bowel like symptoms.

Nexium has active ingredients of esomeprazole magnesium.Loose bowel movements is found among people who take Nexium, especially for people who are female, 60+ old,A study on 114,868 people who have side effects while taking Nexium from FDA. Among them, 6,304 have Loose bowel movements.

Please mention why were you prescribed these medications?
How long did you took these medication i.e Nexium, Senemet, bystolic.?
Have you stopped all three medicines now?
From how long have you stopped them?
What medications are you on at present?

As per your question yes continuous ingestion of these drug can cause the symptoms you are having, But they should subside once you stop the medicine.

Please answer the questions for further explanation.
waiting.
Regard,
Dr Kumar.
Above answer was peer-reviewed by : Dr. Vaishalee Punj
doctor
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Follow up: Dr. Ramesh Kumar (2 hours later)
Dear Dr. XXXXXXX

I only took Sinemet once, quit due to explosive diarrhea. Also the same scenario with Nexium and bystolic. Took once. Diarrhea. Quit. I took ramipril about a month before bad side effects occurred. A terrible unbelievable stomach ache. Quit of course. I am sorry I did not make this clear. My thought was maybe ingesting the drugs caused permanent damage to my stomach lining, especially, the ramipril, as I took it so long and that the IBS and lactose intolerance that came on in a few months after ingesting these drugs was a result of damage caused by them.

Why prescribed these meds-- Sinemet-- Dr. thought because of a tremor in my hand, I had Parkinson's. If so, do not need it. Only symptom is I have bad handwriting. The tremor is on and off.

Nexium-- Dr. thought I had GERD. Really don't

The ramipril and Bystolic-- are for High Blood Pressure. Have since gone on a GF Lisinopril . This was after the found the list of GF drugs mentioned below.

I cannot understand why, after being gluten free for 20 years-- and I am very strict about my diet--I should all of a sudden-- within 6 months or so of taking these drugs, I find I had IBS-C and now have what seems to IBS-D and lactose intolerance. I was put on the FODMAP diet which does not help much. I cannot eat many of the things that are listed as ok to eat on that diet, e.g. carrots and peas. Still have bad time controlling bowel movements and am afraid to go out to eat among other things.

Drugs I take now are lisinopril (Mylan GF) Also temazepam. Some vitamins.

In the USA I find that doctors do not know that some commonly prescribed drugs are not GF and prescribe them without thinking and you get sick. Now I do know that --use the internet list of GF drugs and keep it on my phone.

My basic question is could all this exposure to GF drugs, however short, have damaged my stomach lining or otherwise caused the IBS/lactose intolerance? These things are harder to cope with than the GF diet.

Thanks so much for reading my comments and for your concern.

Regards,
XXXXXXX XXXX
doctor
Answered by Dr. Ramesh Kumar (39 minutes later)
Brief Answer:
Follow up answer!

Detailed Answer:
Hi,
As per your question,
No i don't think that all this is due to exposure to GF drugs.Such a short time exposure can not cause permanent damage to intestinal mucosa or can't lead to lactose intolerance or IBS.
In case you have any other query regarding treatment and differential diagnosis feel free to ask.
Regards,
Dr Kumar.
Note: For further follow up on digestive issues share your reports here and Click here.

Above answer was peer-reviewed by : Dr. Prasad
doctor
Answered by
Dr.
Dr. Ramesh Kumar

Gastroenterologist

Practicing since :1986

Answered : 2906 Questions

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What Causes IBS While On Ramipril, Nexium, Sinemet And Bystolic?

Brief Answer: Side effect of Sinemet Detailed Answer: Hi, Thanks for choosing HealthcareMagic for your query. Have gone through all your details. Sinemet contains Carbidopa and Levodopa, A very common side effect of (Carbidopa-Levodopa) is loose stools. This drug causes an upset stomach, there by irritating the gastrointestinal tract and digestive system. Irritation of the gastrointestinal tract may expedite the shuttling of food through the digestive tract and lead to frequent bowel movements with loose stools. So basically its not exactly irritable bowel syndrome, But as the drug is constantly irritating your gastro-intestinal tract so it causes improper digestion of food with increased motility leading to frequent bowel moments. One way to potentially decrease likelihood of G.i irritation is to take Sinemet along with food or after a big meal; this may reduce gastrointestinal irritation as caused by the medication. However if its detoriating the quality of life then i would advice you to take Clidinium. Don't take imodium;Imodium contains loperamide and is not a safe drug and should be avoided. However Clidinium is very safe and is frequently used to control irritable bowel like symptoms. Nexium has active ingredients of esomeprazole magnesium.Loose bowel movements is found among people who take Nexium, especially for people who are female, 60+ old,A study on 114,868 people who have side effects while taking Nexium from FDA. Among them, 6,304 have Loose bowel movements. Please mention why were you prescribed these medications? How long did you took these medication i.e Nexium, Senemet, bystolic.? Have you stopped all three medicines now? From how long have you stopped them? What medications are you on at present? As per your question yes continuous ingestion of these drug can cause the symptoms you are having, But they should subside once you stop the medicine. Please answer the questions for further explanation. waiting. Regard, Dr Kumar.