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Suggest Treatment For Syphilis
Question: Hello, I got TPHA reactive with 1.4 dillusion. Wat is the treatment to reduce it and make it negative.. I am really tense..plz help
Brief Answer:
Single injection of Benzathine Penicillin is curative
Detailed Answer:
Dear XXXXXXX Hi
I can understand your concern.
TPHA (trepenoma pallidium hemagglutination test) is a screening test done in early cases of syphilis. If TPHA is positive, a nontreponemal test like VDRL should be performed to confirm diagnosis. Therefore, I suggest you to get VDRL done and not to worry as syphilis is completely curable.
Once TPHA is positive, it remains so for life, although there might be no disease and the person is non-infectious but the TPHA remains positive.
A single intramuscular injection of long acting Benzathine penicillin G (2.4 million units) will cure a person who has primary, secondary or early latent syphilis.
Hope this answers your query.
Single injection of Benzathine Penicillin is curative
Detailed Answer:
Dear XXXXXXX Hi
I can understand your concern.
TPHA (trepenoma pallidium hemagglutination test) is a screening test done in early cases of syphilis. If TPHA is positive, a nontreponemal test like VDRL should be performed to confirm diagnosis. Therefore, I suggest you to get VDRL done and not to worry as syphilis is completely curable.
Once TPHA is positive, it remains so for life, although there might be no disease and the person is non-infectious but the TPHA remains positive.
A single intramuscular injection of long acting Benzathine penicillin G (2.4 million units) will cure a person who has primary, secondary or early latent syphilis.
Hope this answers your query.
Above answer was peer-reviewed by :
Dr. Sonia Raina
Hi, i have been diagonosed TPHA reactive with 1.4 dilusion.. what does this mean and what is the treatment.. Doctor have suggested me 1.2 million of penicillin 2 dosage on a single day.. how it can be turn to negative and in how much time?? Also, my wife was pregnant nd been detected in 1st trimester of pregnancy with TPHA positiVe. doctor has given her erythromycin in starting and afterwards in oct. with 3 dosage weekly of penicillin.. bt my baby is also showing VDRL positive.. what can be done to save?? i m really tense..
Brief Answer:
Suggestive of latent syphilis
Detailed Answer:
Dear XXXXXXX Hi
Thanks for your reply, noted its contents.
Reactive TPHA is suggestive of latent syphilis (a sexually transmitted disease).
The prescribed dose of 2.4 million units of Injection Benzathine Penicillin is the standard treatment for latent syphilis. As outlined earlier, the TPHA test may remain reactive even after the treatment is completed or syphilis is cured.
Since your wife was also detected to be positive for syphilis during her pregnancy she was given the treatment by her doctor.
Your baby also seems to be affected by syphilis which is reflected by a positive VDRL (this is referred to as congenital syphilis which may be asymptomatic).
Your baby also needs to be treated
The treatment involves injection Benzylpenicillin 50 mg/kg given intravenously 12-hrly for 7 days and 8-hrly for next 3 days.
An alternative treatment is injection Procaine penicillin G, 50,000 units/kg/day intramuscularly for 10 to 14 days.
For your baby VDRL test should be repeated at 1, 2, 4, 6 & 12 months. It should become nonreactive by 12 months of age if treated appropriately.
Hope the suggestions given above could be useful in getting the treatment done from your doctor.
Best regards.
Suggestive of latent syphilis
Detailed Answer:
Dear XXXXXXX Hi
Thanks for your reply, noted its contents.
Reactive TPHA is suggestive of latent syphilis (a sexually transmitted disease).
The prescribed dose of 2.4 million units of Injection Benzathine Penicillin is the standard treatment for latent syphilis. As outlined earlier, the TPHA test may remain reactive even after the treatment is completed or syphilis is cured.
Since your wife was also detected to be positive for syphilis during her pregnancy she was given the treatment by her doctor.
Your baby also seems to be affected by syphilis which is reflected by a positive VDRL (this is referred to as congenital syphilis which may be asymptomatic).
Your baby also needs to be treated
The treatment involves injection Benzylpenicillin 50 mg/kg given intravenously 12-hrly for 7 days and 8-hrly for next 3 days.
An alternative treatment is injection Procaine penicillin G, 50,000 units/kg/day intramuscularly for 10 to 14 days.
For your baby VDRL test should be repeated at 1, 2, 4, 6 & 12 months. It should become nonreactive by 12 months of age if treated appropriately.
Hope the suggestions given above could be useful in getting the treatment done from your doctor.
Best regards.
Above answer was peer-reviewed by :
Dr. Prasad
sir, I am attaching the VDRL report of baby which is reactive.. plz check.. also baby has been given benzathine pencillin 1 dose within 24 hours of birth. now its 9 day.. plz advice wat to do.. as doctors r saying they will start procaine pencillin course from 14 day for 10 days as benzathine pencillin dose requires gap of atleast 14 days. plz check and tell solution
Brief Answer:
Benzathine penicillin is a long acting penicillin
Detailed Answer:
Dear XXXXXXX Hi
Thanks for your reply, noted its contents and the uploaded result of the lab test.
Yes, Benzathine Penicillin is a long acting penicillin which is usually effective for 3-4 weeks. Since your baby has already been given Benzathine Penicillin, follow the instructions given by his doctor and the course of treatment can be completed with Procaine Penicillin from the days given for at least 10 days.
Hope this answers your query.
Best regards.
Benzathine penicillin is a long acting penicillin
Detailed Answer:
Dear XXXXXXX Hi
Thanks for your reply, noted its contents and the uploaded result of the lab test.
Yes, Benzathine Penicillin is a long acting penicillin which is usually effective for 3-4 weeks. Since your baby has already been given Benzathine Penicillin, follow the instructions given by his doctor and the course of treatment can be completed with Procaine Penicillin from the days given for at least 10 days.
Hope this answers your query.
Best regards.
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Above answer was peer-reviewed by :
Dr. Prasad
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