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Suggest Treatment For Chronic Hepatitis

Posted on Tue, 6 Jun 2017

Question: What does Hep Be Ab-so reactive means?

Answered by Dr. Panagiotis Zografakis (40 minutes later)

Brief Answer:
please upload the full report...

Detailed Answer:
Hello,

this test can't be interpreted on its own. Please upload the complete report (including the rest of the antibodies and antigens) and clinical details like if you have any symptoms or other abnormal tests.

I'll be glad to comment on your case when you send the necessary information!

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Panagiotis Zografakis (28 minutes later)

I did the hepatitis b test and the result show that the HBeAb is reactive and the HBeAg is non reactive?

Answered by Dr. Panagiotis Zografakis (4 minutes later)

Brief Answer:
it may mean two things. Please read the full answer

Detailed Answer:
Hello,

if the HBsAg was negative, the antiHBs positive these are the only tests you did then the potential interpretations are two:
- previous exposure to hepatitis B (acute hepatitis) and complete recovery
- vaccination

If you haven't done the vaccine then it's probably due to previous exposure to the virus. You should probably be positive for HBcore antibody (IgG) and negative for HBcore IgM.

I hope it helps!
Kind Regards!

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Panagiotis Zografakis (7 minutes later)

The surface antigen was réactive and the surface antibody was non reactive

Answered by Dr. Panagiotis Zografakis (21 minutes later)

Brief Answer:
either acute or chronic hepatitis

Detailed Answer:
You'd better upload the full report. If you can't scan it then a simple photo (you can use your XXXXXXX phone) would suffice. So I'm summing up the information you've provided:
HBsAg(+), antiHBs(-), HBeAg(-), antiHBe(+)
Is that right?

The aforementioned pattern may mean either acute or chronic hepatitis. More information is required like the core antibodies and HBV-DNA. Clinical details (your symptoms and biochemical panel) are equally important.

The positive antiHBe usually means low infectivity.
Providing all the details will help me to provide a more accurate and complete answer.

Kind Regards!

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Panagiotis Zografakis (2 hours later)

I have uploaded all the lab report

Answered by Dr. Panagiotis Zografakis (5 hours later)

Brief Answer:
acute or chronic hepatitis

Detailed Answer:
So there are no other tests, no HBe or antiHBe, right?
You haven't mentioned any symptoms either. You've got to understand that test results are always interpreted within a very specific clinical context.
Anyway, the results you've uploaded mean either acute or chronic hepatitis. Regarding the chronic hepatitis possibility, it may be active or just in carrier state. So further testing is require to determine your current status. Clinical information are important as already explained.

The answer you've received from Dr. Madyastha involves a different test result (HBsAg negative and antiHBs positive) like I thought you meant in your first question.

I hope it's clear now. You should visit your primary care doctor for further testing. Further tests should include the antiHBc IgM and IgG, HBV-DNA, antiHDV and liver function tests.

Kind Regards!

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Panagiotis Zografakis (43 minutes later)

I did another test and the result is as follow: HBeAb reactive and HBeAg non reactive

Answered by Dr. Panagiotis Zografakis (2 hours later)

Brief Answer:
not active infection probably

Detailed Answer:
HBeAg(-) and antiHBe(+) means low infectivity and usually means that the infection was active in the past (not currently). The important tests are the ones I've suggested in my previous answer. Depending on the results, more tests might be required.

Kind Regards!

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Panagiotis Zografakis (1 hour later)

here is the overall result: Hbsag reactive, Hbsab non reactive, Hbeag non reactive, Hbeab reactive, ALT 26, AST 48 , albumin lvl 4.4, lipase lvl 29, alk phos 76, bili total 0.6, bili direct 0.2, protein total 7.9, Hep B DNA conc- So 174, Hep B DNA log IU-So 2.24,

Answered by Dr. Panagiotis Zografakis (7 minutes later)

Brief Answer:
upload the actual report please

Detailed Answer:
The biochemical tests are OK. Your gamma globulins are a little on the high side but this is neither too high nor too specific to diagnose anything. I don't understand the HBV-DNA test as you presented it. Please upload the report. A photo would be enough, like with the previous reports.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Panagiotis Zografakis (8 minutes later)

I uploaded the report

Answered by Dr. Panagiotis Zografakis (49 minutes later)

Brief Answer:
follow-up is required

Detailed Answer:
HBV-DNA is detectable in your blood. The levels of HBV-DNA are not high though, so you're probably an inactive carrier of HBV (taking into account the lack of elevated transaminases and symptoms). Follow-up is required to distinguish between the inactive carrier state and chronic active hepatitis with fluctuations in transaminases levels.

Kind Regards!

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Panagiotis Zografakis (4 hours later)

Can I pass it to others if I am inactive carrier of chronic hepatitis b?

Answered by Dr. Panagiotis Zografakis (26 minutes later)

Brief Answer:
yes...

Detailed Answer:
It is possible but the infectivity is much lower than in active states. You should avoid blood to blood contact and use condoms during sexual intercourse.

Kind Regards!

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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar