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Is Hydroxychloroquin An Effective Medication For LPP Disease?

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Posted on Fri, 18 Dec 2015
Question: Hi doctor...this is in continuation to our earlier discussion of LPP disease. You have recommended to use Hydroxycloroquin under doctor's supervision to to stop spread of this skin pigmentation. My question is: is it safe to use this medicine? Also do you think this pigmentation is due to any kind of fungus?
doctor
Answered by Dr. Dr. Kakkar (3 hours later)
Brief Answer:
Hydroxychloroquin is safe

Detailed Answer:
Hi.


Hydroxychloroquin is safe. However, it is recommended to do baseline liver function tests and ophthalmology checkup before starting hydroxychloroquin. These need to be repeated 6 monthly as hydroxychloroqion can rarely have side effects like liver toxicity and side effects related to visual acuity and field of vision. However these are not common and monitoring at 6 monthly interval is a good precaution.

I dont think this pigmentation is related to fungal infection.

Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr. Kakkar (20 minutes later)
The dosage that you have suggested is 200 mg Hydroxychloroquin pills twice daily, morning and evening. So, for how many days I should take it?
Also, I'm using Momate cream daily night for last 15days as you suggested. For how long this need to be continued?
doctor
Answered by Dr. Dr. Kakkar (2 hours later)
Brief Answer:
Treatment last 4-6 months at least

Detailed Answer:
Hi.

Ideally, both of these need to be continued for at least 4-6 months. You need to review every 2-4 weeks with your doctor.

Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Dr. Kakkar (7 hours later)
Thank you Doctor.
while I was browsing net about this LPP, (https://www.dermquest.com/expert-opinions/clinical-updates/2015/blurred-lines-edp-plus-lpp/) got to see a suggestion to apply hydroquinone 4% cream to reduce this pigmentation. May I know your thought around this?
doctor
Answered by Dr. Dr. Kakkar (19 minutes later)
Brief Answer:
Topical steroid is preferred

Detailed Answer:
Hi.

Hydroquinone is one of the treatment options. However, topical steroid i.e mometasone furoate is preferred option for treatment of LPP. Moreover, hydroquinone can have side effects like irritation and can cause exogenous ochronosis as a side effect of long term use.

Regards
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Dr. Kakkar

Dermatologist

Practicing since :2002

Answered : 9612 Questions

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Is Hydroxychloroquin An Effective Medication For LPP Disease?

Brief Answer: Hydroxychloroquin is safe Detailed Answer: Hi. Hydroxychloroquin is safe. However, it is recommended to do baseline liver function tests and ophthalmology checkup before starting hydroxychloroquin. These need to be repeated 6 monthly as hydroxychloroqion can rarely have side effects like liver toxicity and side effects related to visual acuity and field of vision. However these are not common and monitoring at 6 monthly interval is a good precaution. I dont think this pigmentation is related to fungal infection. Regards