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Is HIV Spot Test Done 8 Weeks Post Exposure Conclusive?

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Posted on Tue, 15 Mar 2016
Question: Hello Doctor, I am XXXXXXX I was facing a throat problem and i wanted to brief you the total case.

" I was in Germany begining of Nov 2015 and had 3 sexual encounters in 2 days with Commercial Sex Worker. The sex was unprotected Oral sex full fledged (giving and receiving both) and protected Vaginal intercourse. This was the first time I had such encounter and was really guilty for the incident happened. Actually I was in a drunken and heavily smoking during that time.

After coming back I was really stressed and had oral thrush, and mild sore throat. I took antibiotics for 3 days and was ok. After a week i still have mild irritating throat , mild pain on the lymph nodes.

Finally after 3 weeks of risk exposure i got tested for following:

1. HIV PCR DNA Qualitative : Result NEGATIVE

2. HIV Combo Test (including p24 Antigen) : Result NEGATIVE

3. HIV Antibodies - ELISA (Test strategy -III) - Result NEGATIVE

Also I had also tested for STD (Syphilis, Herpes) which was also Negative.

I also met a doctor and he suggested antibiotics for a week for throat infection. I used the antibiotics but after a week . Also sometimes I still have the mild throat pain ,intermittent pain like squeezing.

Also I had mild pain under the jaws (tonsiltis).

I was really getting worried ,as despite using antibiotics I was still having this irritating throat. Also I developed a rash on the shoulder on 38th day and it has vanished in a day.

I met the doctor again and again he gave antibiotics for a week (Cefpodoxime proxetil) for throat infection. I completed the course of Antibiotics, however I still had very mild throat, sometime on the left side of the throat and right side of throat but rarely on middle of throat and intermittent squeezing pain. however it was only mild and irritating.

So I got tested again as below:

On 41st day HIV Elisa (Test strategy-III) : Negative

On 44th day HIV PCR -RNA- Quantitative- Negative

On 45th day HIV Combo Test (including P24 Antigen) - Negative.

On 53rd day got tested for PCR qualitative test for Gonnoreah and Chlyamdia: Negative

On 56th day HIV Combo Test (including P24 Antigen): Negative

I ve attached all the reports for your reference except the PCR DNA-qualitative report, however it was negative too and was tested at 3 weeks.

Please advise on the following:

Now it is 70 days of exposure again i had mild throat pain, tender and painful lymph nodes and a small rash on my neck area, also had mild muscle pain.

I did gargling for 3 days with salt and used panadol tabs for 2 days. The pain has gone and throat pain is reduced drastically and i stopped gargling as well.

After a day a very mild throat irritating persists. Do I need to start gargling again. Also I was using fucidin for the rash on the neck.

The throat is scratchy and irritating, but no problem while eating and having fluids. Also had icthy ear on both the years.

But I wonder 15 days back I had antibiotics for 2 weeks, i dont know why the throat irritation occurred again.


The doctors said that the HIV Test after 3 weeks and 6 weeks and 8 weeks are negative (both DNA, RNA, Antibodies , P24 Antigen) and are conclusive .

Are these considered conclusive? or do i need t wait for 3 months as per CDC guidelines. I am not having sex with my wife till my doubts are cleared.

Please advise your opinion whether HIV tests are conclusive or still i need to test, as I am planing for kids.

Can you please advise on the medication for irritating throat, why still it persists.

Your reply is highly appreciated.
doctor
Answered by Dr. Mukund Savaskar (5 hours later)
Brief Answer:
Obsession for Throat irritation after unnatural Sex / Under Assessment

Detailed Answer:
Brief Ans-Obsession for Throat irritation after unnatural Sex / Under Assessment

Hi Dear !! Thanks for your detailed query to HCM.

Read your query thoroughly and reviewed its contents in context to your irritating throat.

In My opinion- You seems to have fear Psychosis for HIV after the last oral sex encounter in Germany, because you now want to plan for your kids. But with all this obsession You are afraid that you might contract HIV to your wife.

As your 8 weeks tests are ale already negative, its very unlikely to have HIV positive on 12th week HIV reports.

You have to stabilize your mind first and live normal life. But the repeated throat and skin rash creating doubts in your mind about your having latent HIV.

My Suggestions-

You should just forget about your oral sex encounter, as your reports are not suggestive of HIV on 8th week.

Keep Me updated with your 12 week HIV reports.

Regarding the constriction feel and throat itching , you should continue saline gargles.

LISTERINE gargles would protect you in a better way.

Don't over use antibiotics, as it may contribute to the reduced immunity.
Have healthy high protein diet and plenty of fluids.

Avoid Alcohol and un-natural sex any more here after!!!

My Diagnosis-

You seems to have GERD(Gastro-esophageal Reflux disease) with acid reflux from alcohol? Spicy food ? Sedentary life style?

Which is causing repeated Throat itching and irritation in your case, with attack of infection post -GERD flare up.

Check with your ENT Surgeon for second opinion and EGD-(Esophago-gastro-Duodenoscopy),as it seems your on wrong line for treating with antibiotics each time.

Remedy Suggested -

I would suggest-
PPI-like Lansoprazole with Domperidone - to treat GERD
Cap Zincovit x 3 weeks

Revert to Me after 12 weeks HIV testing-which is going to be negative.
So Don't have obsession of having HIV.

My answers to your following queries are as follows-

Q-1-Do I need to start gargling again. Also I was using fucidin for the rash on the neck.
Ans-1-You should start gargling with Listerine.
And treat the cause of your constriction feeling in throat- which is Acid reflux from alcohol/ spicy diet induced -GERD(Gastro-Esophageal-Reflux Disease),which is the cause of throat irritation with repeated infections in your case.

Q-2-But I wonder 15 days back I had antibiotics for 2 weeks, i dont know why the throat irritation occurred again.
Ans-2-Reason of your throat infection despite of your repeated antibiotics courses - is reduced immunity in your body - from anxiety neurosis with obsession for HIV.
Treat GERD with PPI with motility regulators as suggested and your throat irritation would go for all times.

Q-3-Are these considered conclusive? or do i need t wait for 3 months as per CDC guidelines. I am not having sex with my wife till my doubts are cleared.
Ans-3- I would suggest to Keep Me updated by direct question- with your 12 week HIV report. I would comment further on clearing your doubt at that time .

Q-4-Please advise your opinion whether HIV tests are conclusive or still i need to test, as I am planing for kids.
Ans-4-Though HIV tests are conclusive, as they have proved that HIV is negative at 8 weeks, I would ask you to Keep Me updated after 12 weeks HIV report by a direct question to ME at HCM.This would resolve anxiety neurosis and obsession you have about HIV.

Q-5-Can you please advise on the medication for irritating throat, why still it persists.
Ans-5-Medicines Suggested for your case- are as above-

a-Listerine Mouth Washes
b-Change of Life style and
c-Avoid Alcohol / spices and NEVER to go for commercial sex.
d-PPI -like lansoprazole with domperidone from your GP doctor x for 2 weeks period.
e-Good Bland High protein diet
f-Good 8 hrs sleep
g-Psychiatrist Counselling
h-No Self drugging with antibiotics any more .

Hope this would reply all your queries and worries with it.
Keep Me updated with direct question to Me, whenever you need.
Welcome with any further query in this regard.

Good Day!!

Dr.Savaskar M.N. XXXXXXX Surgical Specialist
M.S.Genl-CVTS.


Above answer was peer-reviewed by : Dr. Arnab Banerjee
doctor
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Follow up: Dr. Mukund Savaskar (2 days later)
Hello Doctor,

Than you for your reply.

I would like to ask you one question, some of the doctors say that the HIV Combo test is a 4th generation test and is generally conclusive at 6 weeks. But i did the testing at 6 weeks and 8 weeks and the result negative.

Still you suggested me to test at 12 week mark, are these tests not conclusive.

Please advise doctor.

Thanks
doctor
Answered by Dr. Mukund Savaskar (3 hours later)
Brief Answer:
Its for matter of more safety for your case...it is suggested at 12 th week

Detailed Answer:
Brief Ans-Its for matter of more safety for your case...it is suggested at 12 th week!!

Hi Dear !! Thanks for the update query....!!
Based on the facts of your query....as you are much worried ... and to be on the safer side I suggested 12 weeks 4th Generation combo test.
Though the current CDC guidelines(latest by june-2014) suggests it to be conclusive by 6 th week on the presently available data, still the research is going on and I would suggest for more safety,for your case , to repeat it on 12 th week,though its not mandatory...!!
Reports of its negativity by 12 th week are varying/confusing/ uncertain and some say that window period could extend till 12 th week.
So to be on the safer side, I would suggest for your case to repeat at 12 th week.Because Your health is more valuable to Me.
So if you can afford, I would suggest you to wait till combo/ duo test report at 12 th week.
Else its your decision....which shall prevail !!!

Hope this reply would help you to take right decision in your case with your doctors there.

Welcome for any further query in this regard.
Keep Me updated if needed 24 x 7.I would love to help you out with latest versions which are most practical.

Good Day !!

Dr.Savaskar M.N. XXXXXXX Surgical Specialist
M.S.Genl-CVTS


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Mukund Savaskar (3 days later)
Hello Doctor,

Thank you for your advise, I am taking Pantaprozole twice a day for gastric problem, B-complex and sporolac for a 10 days (for ulcer on tongue and due to excessive use of antibiotics).

But still I have the throat irritation, but it is not painful.

I am very conscious about diet and having timely food, but only getting tensed about the symptoms and getting the doubt of conclusiveness of HIV report.

Doctor please clarify for my understanding:

After 8 weeks of exposure and negative HIV report, are there any chances of showing symptoms of HIV?

Does stress cause any throat infection, skin rash etc?

Finally 8 week test considered 100% conclusive or 12 week test has to be done?

I did the 4th generation test at Lalpath lab, is this lab reliable?

Your reply is highly appreciated .

Thanks XXXXXXX


doctor
Answered by Dr. Mukund Savaskar (14 hours later)
Brief Answer:
Don't Worry but take all the precautions as suggested !!

Detailed Answer:
Brief Ans-Don't Worry but take all the precautions as suggested !!


Hi, dear thanks for your repeat queries.
Severe guilt and fear of getting HIV is there with you.
Status of the Sex worker is untold. So You don't Know if its only HIV1 / or Only HIV 2 / or Combination infections.
Besides this US FDA approves only one brand of HIV 1 Combo Tests.
US FDA does not approve HIV2 Combo Tests.
Research has it own limitations and CDC guidelines are dependent on acceptable versions from the Experts based on Current Research.
In this Contexts Your worry has only answer, and that is as suggested.
Though the CDC guideline suggest conlusiveness of Combo HIV 1 test at 6 months, as you are going to plan for kids, standard old concept of waiting till HIV testing at or after 12 months which is practiced and accepted worldwide, needs to be considered for the benefit of you and your wife and your progeny, that is -your planned KIDS.
In this Scenario,though I have all your questions for benefit of your satisfaction and removal of your intense worry for the guilt you did, I would reply all updated queries from you as follows-



Q-1-But still I have the throat irritation, but it is not painful.

Ans-1-You should use Pantoprazole D-(domepridone) for 2-6 weeks for the GERD to be relived, which is the main cause of your throat irritation. Besides this anxiety is causing precipitation of throat irritation also ,for which I would advise Psychiatric Consults and Psychiatrist's Counselling

Q-2- but only getting tensed about the symptoms and getting the doubt of conclusiveness of HIV report.Doctor please clarify for my understanding:

Ans-2-As you are tense, this would reduce with Psychiatric Consults and Counselling and needful anti-anxiety medicines with cover from Psychiatrist .Don't self medicate your self as in case of pantoprazole plain, which would add cost without getting desired benefits in your case.
This would clear your understanding about why you get throat irritation.Its from the above 2 factors which need treatment as suggested.


Q-3-After 8 weeks of exposure and negative HIV report, are there any chances of showing symptoms of HIV?

Ans-3-Theoretically as per CDC guidelines chances are 95 % less with HIV negative report with Combo test. But as you are planning to have kids just wait till 12 months.
No additional testing is suggested usually as per CDC guidelines. But as you are planning for KIDS and as you don't know HIV 1 and HIV 2 status of German Sex workers and as you had unprotected Oral Sex many times in 2 days sex encounter, so considering all these reason ,and the limitations of the CDC guidelines, I have already planned the best possible strategy for YOU and for your family.
Combo tests are conclusive only for US FDA approved test which are done only for HIV1 only.So if your commercial sex contact is having HIV 2 also , then in that case 3 months combo test is the only option you have to re-assure based on the old and new CDC guidelines,as explained earlier here in above.

Q-4-Does stress cause any throat infection, skin rash etc?

Ans-4-Anxiety related stress reduces your immune response with increased chances of Viral Rashes.
So go to thr Gym / Get citrus(Vit C rich)-and Vit A rich fruits juices more frequently /and timely bland -nutritious diet,which would reduce both throat infection / skin rashes naturally .


Q-5-Finally 8 week test considered 100% conclusive or 12 week test has to be done?

Ans-5-Yes 8 weeks is more than conclusive but 12 weeks test needs to be done in your case for the reasons explained to you.

Q-6-I did the 4th generation test at Lalpath lab, is this lab reliable?
Ans-6-For this Just Confirm from Lal Path if they have used HIV1 and HIV 2 Combo tests for your testing ?

Hope this would help you to plan further treatment with Me or from doctors there with you.

Welcome for any further query in this regard.
You are welcome to ask further questions.

Regards
Good Day !!

Dr.Savaskar M.N. XXXXXXX Surgical Specialist
M.S.Genl-CVTS




Above answer was peer-reviewed by : Dr. Sonia Raina
doctor
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Follow up: Dr. Mukund Savaskar (1 hour later)
Hello doctor,

You mentioned 12 months in the above message. Is it 12 months are 12 weeks.

4th generation HIV test says HIV 1 &2 Antibodies including P24 Antigen. Do it tests for HIV 2 as well?

Thanks XXXXXXX
doctor
Answered by Dr. Mukund Savaskar (6 hours later)
Brief Answer:
Consider it 12 weeks....!!

Detailed Answer:
Brief Ans-Consider it 12 weeks....!!

Hi Dear !! Thanks for the update query .
Dear read it as 12 weeks and is typing mistake.
Since when you started getting skin rashes by the way?HOw is your general health ??Do you have any accompanying Malaise with morning stiffness in joints and fibromyalgia as such.
Only 1 kit has US FDA approval, for HIV 2 combo test kits.
Just confirm with your Lal Path lab and update ME.

Keep Me updated on more details if needed,so that timely suggestions could be given.

Welcome for any further query in this regard,as there are many variables and limitations which need to be considered and very from case to case.

You are welcome to ask further questions.

Regards
Good Day !!

Dr.Savaskar M.N. XXXXXXX Surgical Specialist
M.S.Genl-CVTS




Above answer was peer-reviewed by : Dr. Vaishalee Punj
doctor
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Follow up: Dr. Mukund Savaskar (25 hours later)
Dear Sir,

I want to ask you a question regarding STD.

I got tested for Syphilis, Herpes, Chlymadia at 3 weeks, but i was under antibiotic for 3days intially and these tests were done after 2weeks gap.

Apparently after 2 weeks of Cefpodoxime and with a gap of a week i got tested for chlyamdia and gonnoreah PCR Tests at 6th week

Can you please clarify whether these tests can be relied as I was having antibiotics.

Please reply.

Thanks XXXXXXX
doctor
Answered by Dr. Mukund Savaskar (3 hours later)
Brief Answer:
Possibility of doubtful Reliability is there, due to antibiotic cover

Detailed Answer:
Brief Ans-Possibility of doubtful Reliability is there, due to antibiotic cover

Hi Dear !! Thanks for the updated query .
Dear,Read and reviewed your updated query.

In the situation you are in , though the specificity of the tests is 99%, the reliability of PCR tests results in your case is doubtful as the bacterial load might not be there due to Antibiotic cover.

I would suggest you to have Consults from Pathologists, to reduce your worry.
Please confirm on this with your Lal Path lab and update to ME.

Q-Can you please clarify whether these tests can be relied as I was having antibiotics.
Ans-Possibility of doubtful Reliability is there, due to antibiotic cover.
Possibility of questionable Reliability is there, as due to antibiotic cover, possibility of organisms in blood/ urine is reduced and so is its detection by Nucleic Acid Amplification Tests-as in PCR test.

This is in-spite of the fact of that the specificity of PCR Chlamydia and gonorrhea is good (99%)

Keep Me updated on more details, if needed.
Welcome for any further query in this regard.

You are welcome to ask further questions.

Regards
Good Day !!

Dr.Savaskar M.N. XXXXXXX Surgical Specialist
M.S.Genl-CVTS

Note: For further follow up on related General & Family Physician Click here.

Above answer was peer-reviewed by : Dr. Arnab Banerjee
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Answered by
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Dr. Mukund Savaskar

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Is HIV Spot Test Done 8 Weeks Post Exposure Conclusive?

Brief Answer: Obsession for Throat irritation after unnatural Sex / Under Assessment Detailed Answer: Brief Ans-Obsession for Throat irritation after unnatural Sex / Under Assessment Hi Dear !! Thanks for your detailed query to HCM. Read your query thoroughly and reviewed its contents in context to your irritating throat. In My opinion- You seems to have fear Psychosis for HIV after the last oral sex encounter in Germany, because you now want to plan for your kids. But with all this obsession You are afraid that you might contract HIV to your wife. As your 8 weeks tests are ale already negative, its very unlikely to have HIV positive on 12th week HIV reports. You have to stabilize your mind first and live normal life. But the repeated throat and skin rash creating doubts in your mind about your having latent HIV. My Suggestions- You should just forget about your oral sex encounter, as your reports are not suggestive of HIV on 8th week. Keep Me updated with your 12 week HIV reports. Regarding the constriction feel and throat itching , you should continue saline gargles. LISTERINE gargles would protect you in a better way. Don't over use antibiotics, as it may contribute to the reduced immunity. Have healthy high protein diet and plenty of fluids. Avoid Alcohol and un-natural sex any more here after!!! My Diagnosis- You seems to have GERD(Gastro-esophageal Reflux disease) with acid reflux from alcohol? Spicy food ? Sedentary life style? Which is causing repeated Throat itching and irritation in your case, with attack of infection post -GERD flare up. Check with your ENT Surgeon for second opinion and EGD-(Esophago-gastro-Duodenoscopy),as it seems your on wrong line for treating with antibiotics each time. Remedy Suggested - I would suggest- PPI-like Lansoprazole with Domperidone - to treat GERD Cap Zincovit x 3 weeks Revert to Me after 12 weeks HIV testing-which is going to be negative. So Don't have obsession of having HIV. My answers to your following queries are as follows- Q-1-Do I need to start gargling again. Also I was using fucidin for the rash on the neck. Ans-1-You should start gargling with Listerine. And treat the cause of your constriction feeling in throat- which is Acid reflux from alcohol/ spicy diet induced -GERD(Gastro-Esophageal-Reflux Disease),which is the cause of throat irritation with repeated infections in your case. Q-2-But I wonder 15 days back I had antibiotics for 2 weeks, i dont know why the throat irritation occurred again. Ans-2-Reason of your throat infection despite of your repeated antibiotics courses - is reduced immunity in your body - from anxiety neurosis with obsession for HIV. Treat GERD with PPI with motility regulators as suggested and your throat irritation would go for all times. Q-3-Are these considered conclusive? or do i need t wait for 3 months as per CDC guidelines. I am not having sex with my wife till my doubts are cleared. Ans-3- I would suggest to Keep Me updated by direct question- with your 12 week HIV report. I would comment further on clearing your doubt at that time . Q-4-Please advise your opinion whether HIV tests are conclusive or still i need to test, as I am planing for kids. Ans-4-Though HIV tests are conclusive, as they have proved that HIV is negative at 8 weeks, I would ask you to Keep Me updated after 12 weeks HIV report by a direct question to ME at HCM.This would resolve anxiety neurosis and obsession you have about HIV. Q-5-Can you please advise on the medication for irritating throat, why still it persists. Ans-5-Medicines Suggested for your case- are as above- a-Listerine Mouth Washes b-Change of Life style and c-Avoid Alcohol / spices and NEVER to go for commercial sex. d-PPI -like lansoprazole with domperidone from your GP doctor x for 2 weeks period. e-Good Bland High protein diet f-Good 8 hrs sleep g-Psychiatrist Counselling h-No Self drugging with antibiotics any more . Hope this would reply all your queries and worries with it. Keep Me updated with direct question to Me, whenever you need. Welcome with any further query in this regard. Good Day!! Dr.Savaskar M.N. XXXXXXX Surgical Specialist M.S.Genl-CVTS.