Brief Answer: Cushings syndrome Detailed Answer: A morning blood test for cortisol is not the correct way to check for the presence of Cushings syndrome. The recommended way is to screen using one of three tests, or a combination of them if the index of suspicion is high. The three tests are 1) 1 mg overnight dexamethasone suppression test. In this test, a 1 mg tablet of dexamethasone is taken close to midnight and a blood sample for cortisol is taken at 8 am the next morning. This is assuming you have normal sleep wake cycle like most people and do not work night shifts 2) Checking for cortisol levels in the saliva close to midnight 3) 24 hour urinary collection for cortisol. So the random blood cortisol test and the values you have shared above are not worth interpreting in the context of trying to ascertain a diagnosis of Cushings syndrome. I have noted your symptoms and advise you to see an Endocrinologist in person because they are the only physicians truly qualified and trained to interpret complex hormone tests.

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Brief Answer: Follow up Detailed Answer: High levels in the morning do not necessarily mean they persist to stay high at night. The only value of a morning cortisol blood test is to rule out the possibility of adrenal insufficiency. It is of little or no value to diagnose Cushings syndrome.For this condition there are several other tests, 3 of which I have described above

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