HealthCareMagic is now Ask A Doctor - 24x7 | https://www.askadoctor24x7.com

question-icon

How Can Abnormal RDW, Platelets, Lymphocytes, EPI Cells And Leukocyte Counts Be Diagnosed?

default
Posted on Thu, 3 Oct 2019
Question: RDW 15.2
Platelets 411
Lymphocytes 40.4
EPI cells. 88
Leukocyte Esterase
WBC UA 9
RBC UA. 7
doctor
Answered by Dr. Bonnie Berger-Durnbaugh (1 hour later)
Brief Answer:
Questions so that I can advise

Detailed Answer:
Hello and welcome,

I'll need additional information to be able to help. Are you wanting this interpreted? To do so, I'll need to know what symptoms you are having that your doctor ordered these tests for, because lab values need to be interpreted in the context of the symptoms. Otherwise, all I can offer is a long list of reasons why certain values are as they are. Also, how do your current lab values compare with past lab tests if done.

It looks like the first 3 values are from a CBC that is automated (not manual).
Platelets 411 and lymphocytes 40, how do these compare with past tests for these?
It looks like the last 4 values are from a urinalysis and was not a clean catch (88 epithelial cells meaning the urine past over the skin cells, making it inaccurate).
It looks like leukocyte esterase was positive - by how much?

Were all other values of the CBC and Urinalysis normal?


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
default
Follow up: Dr. Bonnie Berger-Durnbaugh (18 minutes later)
No symptoms, just annual blood work. These numbers concerned me. The rest were in range
doctor
Answered by Dr. Bonnie Berger-Durnbaugh (1 hour later)
Brief Answer:
Information

Detailed Answer:
Ok, well I'll give you some general information:

The urinalysis was not a clean catch. It's harder to do for women, to pass urine without it passing over skin of the external genitals. When it does, it can pick up all sorts of things. Your's has a lot of skins cells (88 epithelial cells per high power field). So the results aren't terribly accurate. You might ask to repeat it, and while voiding, hold the labia apart with your fingers. The part of the urinalysis that makes me recommend a repeat specifically is that there are more red blood cells (rbcs) than allowable in a normal UA.

RDW (red blood cell distribution width) - this measures how much range there is in the red blood cell sizes. Normal range is 11 - 15% but varies slightly from one lab's standards to the next. RDW needs to be interpreted along with MCV (mean corpuscular volume) which is the average size of the red blood cells.

If RDW is high but MCV is normal, it is usually an false reading due to the lab using EDTA vs citrate. It can also be due to recent bleeding such as from a heavy period. So those two possibilities would be highest on my list of the slightly elevated RDW.

If the RDW is high and MCV is low, it can be due to low iron anemia; if the MCV is high it can be due to low folate of B12 anemia. If all 3 are low (iron, folate, B12) you can get high RDW and normal MCV.

Platelets: By most standards, normal platelet range is 150 to 450. So yours are in range. Anemia, inflammation, and infection can cause platelets to be too high (and sometimes cancer, but generally they are quite high then).

Lymphocytes: This is a type of white blood cell. The count here is given as a percentage which usually means it was automated. What is more important than the percentage is the actual number of lymphocytes. A normal lymphocyte count is 1- 3 (time 10 raised to the 9th power) which, when compared with the other white blood cells is roughly 20-40% of the total white blood cells. Yours is 40.4% so that is within range. It means the sum of your other white blood cells might have been very slightly lower, making the lymphocyte percentage very slightly higher. Or, they are just on the edge of upper end. I can't tell without knowing the absolute number of lymphocytes and other cells (neutrophils/granulocytes, etc). But 40.4% is not worrisome.

So in summary, your CBC does not look concerning, and your urinalysis was contaminated by skin cells and warrants a re-do.







Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
default
Follow up: Dr. Bonnie Berger-Durnbaugh (4 minutes later)
One big correction. My epithelial was 8. Not 88. Does this change any of your findings?
doctor
Answered by Dr. Bonnie Berger-Durnbaugh (50 minutes later)
Brief Answer:
Thoughts on this

Detailed Answer:
Yes it does.

Was the leukocyte esterase positive or negative?
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Bonnie Berger-Durnbaugh

General & Family Physician

Practicing since :1991

Answered : 3134 Questions

premium_optimized

The User accepted the expert's answer

Share on

Get personalised answers from verified doctor in minutes across 80+ specialties

159 Doctors Online

By proceeding, I accept the Terms and Conditions

HCM Blog Instant Access to Doctors
HCM Blog Questions Answered
HCM Blog Satisfaction
How Can Abnormal RDW, Platelets, Lymphocytes, EPI Cells And Leukocyte Counts Be Diagnosed?

Brief Answer: Questions so that I can advise Detailed Answer: Hello and welcome, I'll need additional information to be able to help. Are you wanting this interpreted? To do so, I'll need to know what symptoms you are having that your doctor ordered these tests for, because lab values need to be interpreted in the context of the symptoms. Otherwise, all I can offer is a long list of reasons why certain values are as they are. Also, how do your current lab values compare with past lab tests if done. It looks like the first 3 values are from a CBC that is automated (not manual). Platelets 411 and lymphocytes 40, how do these compare with past tests for these? It looks like the last 4 values are from a urinalysis and was not a clean catch (88 epithelial cells meaning the urine past over the skin cells, making it inaccurate). It looks like leukocyte esterase was positive - by how much? Were all other values of the CBC and Urinalysis normal?