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Hello Again: Can You Help Me Understand How The Brain
Question: Hello again:
Can you help me understand how the brain respond to buspar? Every time I try the medicine I have a good increase in concentration, reduction of interpersonal symptoms, and improvement in the lack of motivation/aversion to responsibility that I always get taking SSRIs.
The benefit happens very quickly, but only lasts a few days and then I become very angry and judgmental. I never have gotten above 15mgs.
I am reaching the point in my current citalopram treatment where I am again experiencing apathy regarding self care/chores (This always happens with SSRIs for me). For some reason my brain will do anything to avoid responsibility: waking up, leaving for work, folding the laundry that's been on my bed for two weeks.
I know that I can add buspar and this will clear up for a few days but it has never worked in the long run. I know the therapeutic effect can take weeks, but it must have some immediate actions that are helping or blocking my body's reaction to the SSRI. I'd like to determine what this is so that I can try to find this mechanism in another drug. Thanks!
Can you help me understand how the brain respond to buspar? Every time I try the medicine I have a good increase in concentration, reduction of interpersonal symptoms, and improvement in the lack of motivation/aversion to responsibility that I always get taking SSRIs.
The benefit happens very quickly, but only lasts a few days and then I become very angry and judgmental. I never have gotten above 15mgs.
I am reaching the point in my current citalopram treatment where I am again experiencing apathy regarding self care/chores (This always happens with SSRIs for me). For some reason my brain will do anything to avoid responsibility: waking up, leaving for work, folding the laundry that's been on my bed for two weeks.
I know that I can add buspar and this will clear up for a few days but it has never worked in the long run. I know the therapeutic effect can take weeks, but it must have some immediate actions that are helping or blocking my body's reaction to the SSRI. I'd like to determine what this is so that I can try to find this mechanism in another drug. Thanks!
To clarify, I know that buspirone has pre and post synaptic actions at 5ht1a mainly, plus action on ht2, and d2 receptors. I also know I am a poor metabol if the metabolite 1-pp.
One of these mechanisms is fast acting and responsible for the short term relief I get
One of these mechanisms is fast acting and responsible for the short term relief I get
Brief Answer:
Consultation
Detailed Answer:
Hello,
Thanks for using Healthcaremagic.
I read your query and understand your concerns.
First of all I like to inform you that immediate effects of buspirone are largely related with action on dopamine receptors which increases concentration and motivation by acting through the reward system of brain.
The low dose of buspirone is generally selective for dopamine receptors (to small extent) and that could be reason for selective action on dopamine receptors and no or limited action on serotonin receptors.
Although you might be aware, I like to inform you that Vilazodone is one of the antidepressants which can be considered SSRI + Buspirone due to different profile of action. Considering this fact a discussion can be initiated with your doctor to go for vilazodone instead of older SSRI medications to counter apathy and amotivation associated with SSRIs.
I hope this helps you.
Feel free to write back to me if you have more questions.
Thanks and regards.
Consultation
Detailed Answer:
Hello,
Thanks for using Healthcaremagic.
I read your query and understand your concerns.
First of all I like to inform you that immediate effects of buspirone are largely related with action on dopamine receptors which increases concentration and motivation by acting through the reward system of brain.
The low dose of buspirone is generally selective for dopamine receptors (to small extent) and that could be reason for selective action on dopamine receptors and no or limited action on serotonin receptors.
Although you might be aware, I like to inform you that Vilazodone is one of the antidepressants which can be considered SSRI + Buspirone due to different profile of action. Considering this fact a discussion can be initiated with your doctor to go for vilazodone instead of older SSRI medications to counter apathy and amotivation associated with SSRIs.
I hope this helps you.
Feel free to write back to me if you have more questions.
Thanks and regards.
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
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