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Question: Hello Doctor !
You are smart - could you pleas help me understand Antiphospholipid syndrome risk in thous who have antibodies but have not developed DVT or other associated disease
Does early treatment with hydroxychloroquine when there is antiphospholipid antibody will lower the antibody and riks of Antiphospholipid syndrome ?
there was one study about Lyme disease and antiphospholipid antibody and risk of vascular events like stroke
1.Can early antiphospholipid antibody treatment lower antibodies and reduce such risk ?
Seventeen of 106 patients had aPL-related
events (14 vascular events, three recurrent fetal
loss;Table 3).10,11,18 Neurologic symptoms occurred
https://sci-hub.se/10.1177/0000
2. ther was case with chronic HCV and risk of tromb event in patients with antiphospholipid antibodies
Does early HCV treatment will decrease antiphospholipid antibodies and reduce risk of trombolic events ?
Thromboembolic
events were most prevalent in patients with elevated aPL antibodies who had HCV (9.1%,
95% CI 3.0–18.1), and HBV (5.9%, 95% CI 2.0–11.9) infections, and pregnancy events were
most prevalent in those with parvovirus B19 (16.3%, 95% CI 0.78–45.7). However, compared
to virus-infected patients with negative aPL antibodies, the only statistically significant
increased risk was observed in those with HCV and positive aPL. Conclusions: Viral infection
can increase the risk of developing elevated aPL antibodies and associated thromboembolic
events. Results are contingent on the reported information
https://sci-hub.se/https://doi.org/10.1177/0000
You are smart - could you pleas help me understand Antiphospholipid syndrome risk in thous who have antibodies but have not developed DVT or other associated disease
Does early treatment with hydroxychloroquine when there is antiphospholipid antibody will lower the antibody and riks of Antiphospholipid syndrome ?
there was one study about Lyme disease and antiphospholipid antibody and risk of vascular events like stroke
1.Can early antiphospholipid antibody treatment lower antibodies and reduce such risk ?
Seventeen of 106 patients had aPL-related
events (14 vascular events, three recurrent fetal
loss;Table 3).10,11,18 Neurologic symptoms occurred
https://sci-hub.se/10.1177/0000
2. ther was case with chronic HCV and risk of tromb event in patients with antiphospholipid antibodies
Does early HCV treatment will decrease antiphospholipid antibodies and reduce risk of trombolic events ?
Thromboembolic
events were most prevalent in patients with elevated aPL antibodies who had HCV (9.1%,
95% CI 3.0–18.1), and HBV (5.9%, 95% CI 2.0–11.9) infections, and pregnancy events were
most prevalent in those with parvovirus B19 (16.3%, 95% CI 0.78–45.7). However, compared
to virus-infected patients with negative aPL antibodies, the only statistically significant
increased risk was observed in those with HCV and positive aPL. Conclusions: Viral infection
can increase the risk of developing elevated aPL antibodies and associated thromboembolic
events. Results are contingent on the reported information
https://sci-hub.se/https://doi.org/10.1177/0000
Brief Answer:
It’s a wide field of high interest this syndrome for us in medicine
Detailed Answer:
Hello and welcome back in HCM
Thank you for your question.It is such an interesting and a difficult one indeed.
Anti phospholipid syndrome is not a usual one.We see it rarely. It might be a cause of venous embolism especially in younger patients.
1.Yes treating early helps a lot to low the risk of thrombotic events in the body and this is the main reason for its treatment
2.No early treatment of have is not related directly to this syndrome.However these patients with apl and hepatitis c must be treated urgently for it because this condition might be life threatening for them.
There are several interesting cases in apl patients given the fact that this syndrome belongs to systemic autoimmune diseases and can damage all organs.
Regards
Dr.Jolanda
It’s a wide field of high interest this syndrome for us in medicine
Detailed Answer:
Hello and welcome back in HCM
Thank you for your question.It is such an interesting and a difficult one indeed.
Anti phospholipid syndrome is not a usual one.We see it rarely. It might be a cause of venous embolism especially in younger patients.
1.Yes treating early helps a lot to low the risk of thrombotic events in the body and this is the main reason for its treatment
2.No early treatment of have is not related directly to this syndrome.However these patients with apl and hepatitis c must be treated urgently for it because this condition might be life threatening for them.
There are several interesting cases in apl patients given the fact that this syndrome belongs to systemic autoimmune diseases and can damage all organs.
Regards
Dr.Jolanda
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Thank you for your answer !
1. why Antiphospholipid Syndrome affect more younger generation that older - APS between 20 and 50 years age (from literature)
as antibodies more common in older generation
- Low aCL levels are found in up to 10% of healthy individuals, and the prevalence of a positive aPL test increases with age
2. maybe you didnt understand my question - does early HCV therapy - cure, will lower the antiphospholipid antibodies level and reduce trombosis risk ?
2. in patients that have aPl antibodies for long time, persistent - in moderate level ‘aCL 40–79U but have no symptoms, should they be treated - with medicine that lower aPl antibodies levels or no ?
Are they at high risk of developing Antiphospholipid Syndrome ?
1. why Antiphospholipid Syndrome affect more younger generation that older - APS between 20 and 50 years age (from literature)
as antibodies more common in older generation
- Low aCL levels are found in up to 10% of healthy individuals, and the prevalence of a positive aPL test increases with age
2. maybe you didnt understand my question - does early HCV therapy - cure, will lower the antiphospholipid antibodies level and reduce trombosis risk ?
2. in patients that have aPl antibodies for long time, persistent - in moderate level ‘aCL 40–79U but have no symptoms, should they be treated - with medicine that lower aPl antibodies levels or no ?
Are they at high risk of developing Antiphospholipid Syndrome ?
Brief Answer:
If there are antibodies present than treat
Detailed Answer:
Hi again
1.As an autoimmune disease mostly it has a genetic factor and it is diagnosed in young age.In these cases we are talking for the primary apl.The secondary apl is in older ages but it is caused from other autoimmune disorders.
2. Treatment for hep C doesn’t cure apl at all and also it’s risk for tromboses
2. If there are antibodies present it is apl syndrome and should be treated absolutely even in absence of the symptoms
Hope to have been helpful
Regards
Dr.Jolanda
If there are antibodies present than treat
Detailed Answer:
Hi again
1.As an autoimmune disease mostly it has a genetic factor and it is diagnosed in young age.In these cases we are talking for the primary apl.The secondary apl is in older ages but it is caused from other autoimmune disorders.
2. Treatment for hep C doesn’t cure apl at all and also it’s risk for tromboses
2. If there are antibodies present it is apl syndrome and should be treated absolutely even in absence of the symptoms
Hope to have been helpful
Regards
Dr.Jolanda
Note: For further follow up on related General & Family Physician Click here.
Above answer was peer-reviewed by :
Dr. Saisudha Kotla
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