Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
154 Doctors are Online

Family history of crohn's. How to get checked for crohn's disease?

User rating for this question
Very Good
Answered by

General & Family Physician
Practicing since : 1978
Answered : 5669 Questions
Question
hi have a family history of chrohns how does one be checked for chrohns disease? just via bloods?
Posted Fri, 20 Jul 2012 in Chron's Disease
 
 
Answered by Dr. Pavan Kumar Gupta 2 hours later
Hello and thanks for the query.
Crohn's disease is a difficult condition to diagnose since the symptoms can point towards a variety of different conditions. At first, the symptoms can begin as subtle and vague. Over time, the symptoms may become more severe and indicative of Crohn's disease. Sometimes, patients will not receive an accurate diagnosis for years.
Of all possible tests, a colonoscopy is the most effective, since the condition may be in parts of the bowel that are difficult to otherwise examine.If only the ileum is affected, Crohn's disease cannot be diagnosed through a colonoscopy. Blood tests can help doctors achieve an accurate and thorough diagnosis. Anemia that is caused by a management of crohn's disease.
 Antibodies to various proteins including Baker's or Brewer's yeast (saccharomyces cerevisiae) and bacteria like Escherichia. coli (E. coli) are present in the blood of many people with Crohn's disease but rarely in normal people. 
The blood tests currently available are anti-ASCA, anti-OmpC, and anti-CBir1 flagelin antibodies.But these tests are not done in all laboratories.

ASCA is anti-saccharomyces cerevisiae antibody. Saccharomyces cerevisiae is Brewer's or Baker's yeast. Crohn's patients have a high prevalence of abnormal antibodies to this yeast. 
 OmpC is the abbreviation for an antibody that develops in many Crohn's patients to the outer membrane porin protein of the bacteria E. coli though that bacteria is not thought to be the cause of Crohn's disease.
 Just recently Prometheus Laboratories added antibody testing for a specific protein on bacteria that constitutes the flagelin or hair like structure on certain bacteria enabling movement and attachment of bacteria in the intestine called CBir1 flagelin.

The mainstay for the diagnosis of crohn's however is colonoscopy along with biopsy.
The blood tests are relatively very new and not being done everywhere.
I hope to have answered your query however you may revert to  me or any other query.
Best of luck.
Thanks
Above answer was peer-reviewed by
 
Share on Facebook
Share on Twitter
Share on Google+
Question is related to
Medical Procedures
Medical Topics

The user accepted the expert's answer

Ask a Gastroenterologist

©2014 Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions