Question: I am a 57 year old morbidly obese Caucasian man who is being treated for high blood pressure. I’m routinely tested for glucose and lipid levels and that is normal. So are my PSA results. I routinely take Zoloft and/or Wellbutrin for chronic depression. Several years ago – about the time I was 50 – I began experiencing the need to go to the bathroom very frequently. This was accompanied by a extremely strong urge to go. And a few times this resulted in a momentary loss of bladder control when I was wide awake. This passed and my daytime visits are no different now than they were before – or as anyone else’s. About the same time that the troubling day patterns faded I have had a problem with excessive nocturnal urination and adult onset enuresis. (I suffered from enuresis as a child from the time I was 8 until early adolescence; it ended when I began medication for depression.) The issue related to urination is frequency and volume. On average I wake up every hour – or I wake up in a wet bed. I’ve measured the volume of nighttime urine production and that averages 1-1.5 liters per night; sometimes as much as 2 liters. If I am particularly tired and don’t wake up it’s not uncommon to experience multiple episodes of enuresis in a single night. The frequency of urination and episode of enuresis do not seem to vary much even when I restrict my liquids and caffeine consumption. This does impact volume. I sleep with several pillows under by neck and back to avoid snoring and sleep apnea. The onset of this was preceded a rapid gain of a significant amount of weight due to poor diet and inactivity that was triggered by depression and knee injuries. . I don’t know if bladder problems are related or coincidental. These days I’m on a fairly restrictive diet and I’m pursuing an exercise program; to loose the weight or as preparation for bariatric surgery. I probably consume 1 - 1.5 liters of caffeinated beverages a day; none after 4pm. I eat dinner late, by necessity, and usually have soup or salad which are water based. I mentioned this to my PCP and his position was that we needed to deal with the weight first. Thoughts please on what I’m experiencing and what I can do about it.