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Does Provera Increase The Progesterone Levels?

Posted on Mon, 5 Oct 2015

Question: I was waiting to start an IVF cycle with a new clinic but couldn't get an appointment with the doctor until after day 22. So I started taking Provera as I had taken at my old clinic. The nurses told me this afternoon that I can't do a long regulation cycle as my Progesterone levels are too low (7.5 & they prefer over 10). Did the Provera increase or decrease my progesterone levels? I've read it's used in IVF to bring on a period. I'm not sure what the impact has been. Thanks. Does this mean I can't do a long down regulation this cycle? If not, why not? How do the drugs work?

Answered by Dr. Mahesh Koregol (1 hour later)

Brief Answer:
You can go ahead with long down regulation cycle

Detailed Answer:
Hi,

I understand your concerns about progesterone levels.

Provera is also a progesterone hormone and increases the blood levels of progesterone.

You can go ahead with long down regulation cycle though your progesterone is less than 10. This is not an indication for preventing long down regulation cycle. I am not sure why they refused to do long down regulation cycle.

Since you are 41 years, you will benefit with short antagonist cycle. Long down regulation cycle is likely to cause more suppression in your case. Please discuss the possibility of short antagonist cycle in your case.

Let me know if you need any more help.

Regards,
Dr. Mahesh Koregol.
IVF & infertility Specialist

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Mahesh Koregol (1 hour later)

Thank you Dr Koregol. You've given me information to open the discussion with them. So by taking the Provera it would've increased the natural progesterone levels in my blood - is that correct?

Thank you.
XXXX

Answered by Dr. Mahesh Koregol (2 hours later)

Brief Answer:
Not very high levels

Detailed Answer:
Hi,

Provera does not contain natural micronised progesterone. The increase in progesterone levels will be very less with provera. Any way it is not important issue at all to start long protocol with down regulation.

Short antagonist cycle is best for you.

Regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar