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Does Metformin Interact With Glipizide?

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Posted on Mon, 14 Nov 2016
Question: Hello, I was taking metformin 2500 per day along with glipizide 20 mg per day. not getting the results needed. For one week now dropped the glipizide and introduced to onglyza 5 mg per day. not getting the results needed. can glipizide and onglyza be taken together along with metformin ?
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Answered by Dr. Elona (1 hour later)
Brief Answer:
Yes ,this drugs can be taken together.

Detailed Answer:
Hi dear user,
I have gone through your question.
I can understand your concern

Metformin ,glizipide and onglyza(saxagliptin) are oral diabetes medicines that help control blood sugar levels. Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Saxagliptin works by regulating the levels of insulin your body produces after eating.Glipizide helps control blood sugar levels by helping your pancreas produce insulin.
This drugs are used together with diet and exercise to treat type 2 diabetes.

The triple therapy :Glipizide,Onglyza and Metformine is possible.This drugs can be used together and saxagliptin may help control blood glucose levels, which may lead to a reduction in your dosage requirement of glipizide and metformine and reduce potential for unwanted side effects.

I sugget to talk with your endocrinologist about this combination and remember that your blood glucose should be closely monitored so that medications may be adjusted accordingly by your doctor to assure the best results.

Low blood sugar (hypoglycemia) can happen with this therapy.Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. My advice is : Always keep a source of sugar with you in case you have low blood sugar.

Hope I have answered your question. If you have any further questions I will be happy to help.
Thank you for using HCM.
Wish you good health.
Note: For further follow-up, discuss your blood glucose reports with our diabetologist. Click here.

Above answer was peer-reviewed by : Dr. Vaishalee Punj
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Answered by
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Dr. Elona

Endocrinologist

Practicing since :2008

Answered : 939 Questions

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Does Metformin Interact With Glipizide?

Brief Answer: Yes ,this drugs can be taken together. Detailed Answer: Hi dear user, I have gone through your question. I can understand your concern Metformin ,glizipide and onglyza(saxagliptin) are oral diabetes medicines that help control blood sugar levels. Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Saxagliptin works by regulating the levels of insulin your body produces after eating.Glipizide helps control blood sugar levels by helping your pancreas produce insulin. This drugs are used together with diet and exercise to treat type 2 diabetes. The triple therapy :Glipizide,Onglyza and Metformine is possible.This drugs can be used together and saxagliptin may help control blood glucose levels, which may lead to a reduction in your dosage requirement of glipizide and metformine and reduce potential for unwanted side effects. I sugget to talk with your endocrinologist about this combination and remember that your blood glucose should be closely monitored so that medications may be adjusted accordingly by your doctor to assure the best results. Low blood sugar (hypoglycemia) can happen with this therapy.Symptoms include headache, hunger, sweating, confusion, irritability, dizziness, or feeling shaky. My advice is : Always keep a source of sugar with you in case you have low blood sugar. Hope I have answered your question. If you have any further questions I will be happy to help. Thank you for using HCM. Wish you good health.