Brief Answer:
Yes CEA levels drop in presence of Irinotecan therapy

Detailed Answer:
Hi Sir,

I understand your query and concern.

Irinotecan is very useful drug efficient in almost all the cancer patients of colonic cancer,particularly with wide spread disease.

Yes CEA levels should certainly drop in presence of irinotecan therapy.

Thank you.

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Brief Answer:
Possible new mets? Require PET scan evaluation.

Detailed Answer:
Hi Mam,

I understand your concern.

CEA in your case seems to be on increasing note.

This suggests possible new mets rather than in capable drug.

Its highly recommended that your father undergoes a total body PET scan at the earliest to document the location of new growths if any along with a complete study of the solitary met with one aortocaval node.

Also Solitary liver met can be safely resected in most cases to prevent progression/relapse of the underlying cancerous process.

Thank you.

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Brief Answer:
Yes such a possibility exists.

Detailed Answer:
Hi Mam,

Yes there is a possibility of developing new mets even while being on therapy with Irinotecan,if the tumor cells undergo/acquire new spontaneous mutations.

Irinotecan even though a highly effective drug ,will not completely protect against newly mutated cells.

Thank you.

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Brief Answer:
Cancer extension beyond muscle wall

Detailed Answer:
Hi,

This report implies extension of colonic cancer beyond the wall of the intestine outside the muscle coat.

From inside to outside the layers in the colon are named as 1,2,3,4.

Muscle coat is layer 3.

Cancer begins in layer 1 and spreads outside to involve 2,3,4.

Extramural implies the location of cancer between layers 3 and 4.

Thank you.

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