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Does Cyclobenzaprine Interact With Zoloft?

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Posted on Mon, 14 Nov 2016
Question: Does Cyclobenzaprine conflict with zoloft?
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Answered by Dr. Bonnie Berger-Durnbaugh (2 hours later)
Brief Answer:
Yes, it is not advisable to take both.

Detailed Answer:
Hello and welcome

Cyclobenzaprine and Zoloft together can have major, although rare, side effects. The problem with taking both is that they both can increase serotonin, and this can cause a serious and potentially life threatening "serotonin syndrome".

A safer choice with Zoloft, if you need something to relax your muscles, such as after an injury, would be a medication in the benzodiazepine family such as lorazepam or others.

I hope this information helps.
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Bonnie Berger-Durnbaugh

General & Family Physician

Practicing since :1991

Answered : 3134 Questions

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Does Cyclobenzaprine Interact With Zoloft?

Brief Answer: Yes, it is not advisable to take both. Detailed Answer: Hello and welcome Cyclobenzaprine and Zoloft together can have major, although rare, side effects. The problem with taking both is that they both can increase serotonin, and this can cause a serious and potentially life threatening "serotonin syndrome". A safer choice with Zoloft, if you need something to relax your muscles, such as after an injury, would be a medication in the benzodiazepine family such as lorazepam or others. I hope this information helps.