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Do Normal Levels Of 11-deoxycortisol Indicate Adequate ACTH Reserves?

Posted on Wed, 12 Sep 2018

Question: Hello. 10 years ago I was diagnosed with Cushing's Disease. An acth-producing adenoma was removed from my pituitary gland. Later I underwent a radiation procedure. I ended up being hypo pituitary.

My cushing's symptoms have returned, and I am going to have a lot of testing.

My 11-deoxycortisol (serum) level was in the lab's normal range. I believe this means that I have adequate ACTH reserves. Does this also mean that I must be producing acth on my own again?

Answered by Dr. Mirjeta Guni (54 minutes later)

Brief Answer:

Some more info needed.

Detailed Answer:

Hello,

11 deoxycortisol is not the only lab exam that confirms or rules out an overproduction of ACTh and cortisol.

You need to check ACTH and free urinary cortisol at the 24-hour urine.

The fact that 11 deoxy is within the normal ranges is a good news.

If you have other blood tests, please attach them.

Hope I have answered your query.

Take care

Regards,
Dr Mirjeta Guni, Endocrinologist

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Above answer was peer-reviewed by : Dr. Kampana