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Can The X-Linked Agammaglobulinemia Have An Impact On The HIV Test?

Posted on Wed, 28 Jan 2015

Question: X-Linked Agammaglobulinemia

Is it possible you could have this and not know about it . I am concerwnd because i have recently taken hiv teats which were negative after 2 years . I read that if you had this illness it would affect the results . Thanks

Answered by Dr. Bharatesh Devendra Basti (31 minutes later)

Brief Answer:
Unlikely to be reason to cause test negative.

Detailed Answer:
Hi
Thank you for query.I am Dr Bharatesh D Basti answering your query.

I feel you are too anxious about HIV.

Yes, it is right that x linked agammaglobulinemia have deficiency in production of antibodies.
So, there are chances of HIV test coming negative for antibodies.

These diseases are rare. The manifestation starts in infancy itself with repeated respiratory, skin infections etc. Has any other male members in your family been diagnosed with disease. It mainly affects males and is hereditary.

Do not think of rare diseases which is unlikely unless you/other members have manifestations.
It is unlikely that HIV test is negative due to this disease. Allay fears of HIV.

You can get back for any clarification.

Thank you
Dr Bharatesh D Basti
Dermatologist and venereologist

Above answer was peer-reviewed by : Dr. Ashwin Bhandari

Follow up: Dr. Bharatesh Devendra Basti (29 minutes later)

Hi i am not aware of anyone in my family with this . Would you know if you had this ie reacurrent infections ect ? What do tou mean by manifestations . Is this a illnes where if you did have it you would allready know of thanks

Answered by Dr. Bharatesh Devendra Basti (13 minutes later)

Brief Answer:
Yes. You would have known earlier.

Detailed Answer:
Hi,

Thank you for follow up query.

It is associated with repeated Infections like sinusitis, pneumonia, diarrhea, ear Infections etc.
These manifestations can start in infancy or childhood. These infections tend to be recurrent and needs antibiotic repeatedly. You would have been diagnosed earlier itself.

Also probably it would have been diagnosed in male members in your family as it is a hereditary disease.

So forget about all these rare disease. It is unlikely.

You can get back for any clarification.
Thank you
Dr Bharatesh D Basti

Above answer was peer-reviewed by : Dr. Ashwin Bhandari

Follow up: Dr. Bharatesh Devendra Basti (36 minutes later)

I do suffer with ear problems and stomach . But i have never had phneumonia or other ilnesess you stated. Would it of been obvoius if you had this ie you would of had illnesses that would of made you that sick you would of been in hospital ect .

Answered by Dr. Bharatesh Devendra Basti (24 minutes later)

Brief Answer:
Need not require hospitalisation.

Detailed Answer:
Hi,

Thank you for follow up query.

It may not be serious such that it requires hospitalisation. The symptoms need not be due to agammaglobulinemia.

You need not worry about such rare diseases.

Thank you
Dr Bharatesh D Basti

Above answer was peer-reviewed by : Dr. Ashwin Bhandari

Follow up: Dr. Bharatesh Devendra Basti (47 minutes later)

I had baby ashtma but that rid itself later in life . Also i used to get reacurrent tonsilitus untll i had them taken out. Would any of these suggest this disease . I have read it would of been reaccurant bronchial tract infections. If you had the disease and were not treated would i pf been poorly ill by my age of 31 thanks

Answered by Dr. Bharatesh Devendra Basti (1 hour later)

Brief Answer:
Not due to agamaglobulinemia

Detailed Answer:
Hi
Thank you for follow up query.
Asthma and agamaglobulinemia are not related.
Tonsillitis is quite recurrent and common in children and also not related .
Respiratory Infection would have been more recurrent if agamaglobulinemia.
Do not think about it .
So nothing to worry about this rare disease.

Thank you
Dr Bharatesh D Basti

Above answer was peer-reviewed by : Dr. Raju A.T

Follow up: Dr. Bharatesh Devendra Basti (1 hour later)

So if i had this illness it would of been apparant at a young age due to varous illness infection ect . Hypotheticly if this wasnt diagnosed as a child what would the long term prognosis be . Ie would you be sick a lot

Answered by Dr. Bharatesh Devendra Basti (5 hours later)

Brief Answer:
Presented in childhood itself.

Detailed Answer:
Hi
Thank you for follow up query.
Yes would have got repeated infections since childhood.It would gave continued now too or may have worsened.
You are getting anxious of a rare disease whuch is not a possibility in your case.
Thank you
Dr Bharatesh D Basti

Above answer was peer-reviewed by : Dr. Raju A.T

Follow up: Dr. Bharatesh Devendra Basti (11 hours later)

Ok in 2008 i found a lump in my neck reported it to my gp . He took blood samples and sent them off. All ok . If there was an imune blood problem would my sample of been picked up in that test

Answered by Dr. Bharatesh Devendra Basti (3 minutes later)

Brief Answer:
Yes.

Detailed Answer:
Hi
Thank you for follow up query.

Yes probably there would have been suspicion at least from the blood reports .
Do not worry too much.
Just relax.

Thank you
Dr Bharatesh D Basti

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Follow up: Dr. Bharatesh Devendra Basti (1 hour later)

Would you not recomsnd a b and t cell blood check . Or am i being stupid over the top i am just thinking of every eventuality like when i had a acl reconstruction it got infected so i worry that i have something wrong wirh my imune system ect . How rare is that disorder and can you reasure me

Answered by Dr. Bharatesh Devendra Basti (17 minutes later)

Brief Answer:
Rare disorder .No possibility in your case.

Detailed Answer:
Hi
Thank you for follow up query.

It is very rare almost 1 in million or higher .
So there is no possibility of this disease.
You are getting entangled in the web of agamaglobulinemia without any reason.I do not see any need for further investigation.

I do not see any reason for you to worry about it.
You can get back for any clarification.
Thank you
Dr Bharatesh D Basti

Above answer was peer-reviewed by : Dr. Vaishalee Punj

Follow up: Dr. Bharatesh Devendra Basti (27 minutes later)

I had excema when i wss young i have had it most my life not as bad as when i was little. Also i had asthma whwn i was little but grew out of that . If i had that disease what sypmtons would i have now or would of experienced . I am worried that i may of not been diagnosed propperly whwn i was young . I was a pale kid skinny in my youth but since school i have led a active life. I used to pick up coughs and cold a lot when i was young and had impetago also . Would these conditions of got worse or been consistant . Would you of had reacurrent phneumonia ect throughout your life which i havent had.

Answered by Dr. Bharatesh Devendra Basti (1 hour later)

Brief Answer:
Take physician opinion.

Detailed Answer:
Hi
Thank you for follow up query.
The symptoms of eczema, asthma , cough (allergic probably)are related to allergies and are not due to agamaglobulinemia.
Allergic diseases varies with exposure to allergens.

You are trying to fit all symptoms to this disease.
I do not see any possibility of agamaglobulinemia with these symptoms.

You can consult physician for a opinion if you still feel there are chances of agamaglobulinemia.They are the best persons to evaluate.
You can get back for any clarification.
Thank you
Dr Bharatesh D Basti

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Above answer was peer-reviewed by : Dr. Vinay Bhardwaj