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Can SVR 12 Give Accurate Results About Hepatitis C Infection?
Question: How reliable is svr12 of a hep c cure? I'm svr12 and my hepatologist says I am cured. I am the hardest to treat , geno 3, cirrhotic, high viral load, diabetic. Recent studies say svr12 is pretty much 100 percent accurate as svr24 (the old standard) in predicting a cure. Being the hardest to treat what are my chances that this is a cure? Can I figure 100 percent also?
Thank You, XXXXXXX
Thank You, XXXXXXX
Brief Answer:
Cure rates cannot be 100% in presence of Cirrhosis.
Detailed Answer:
Hi Sir,
I understand your concern.
SVR 12 has very good predictability of the cure rates even in presence of high viral load,genotype 3 and diabetic state.
But in the presence of cirrhosis,SVR 12 is not a good predictor.
Survival/Cure cannot be 100 % in presence of cirrhotic liver.
This could be a communication error.
Post your further queries,if any.
Thank you.
Cure rates cannot be 100% in presence of Cirrhosis.
Detailed Answer:
Hi Sir,
I understand your concern.
SVR 12 has very good predictability of the cure rates even in presence of high viral load,genotype 3 and diabetic state.
But in the presence of cirrhosis,SVR 12 is not a good predictor.
Survival/Cure cannot be 100 % in presence of cirrhotic liver.
This could be a communication error.
Post your further queries,if any.
Thank you.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
How about svr24, is that pretty much 100 percent in the presence of cirrhosis?
Brief Answer:
SVR 24 is better predictor of cure in Cirrhosis complicated HCV
Detailed Answer:
Hello Sir,
I understand your concern.
Let me explain the following lines to you.
You have been on Triple drug regimen of Sofusbuvir,Ribavarin and Peg-IF.
You also stated that you attained SVR12 in Dec 2014.This is a Good sign.
This indicates that you have shown good response to the drugs,as there is 2-log fold reduction of viral load.
Patients who develop SVR12 are the candidates for further extension of treatment to 24 weeks ,since only 65% of patients only go onto develop SVR12-which is only a an indication of early virological response.
The duration of treatment in presence of Cirrhosis is 24 months,hence SVR 24( an indication of late virological response) is attained in approx 97% patients(but not 100% here as well),who are considered potentially cured of the infection.
97% itself is an excellent score.
Hence SVR24 is a better predictor of possible cure of infection( with least risk of recurrence of infection) in patients with Cirrhosis.
Thank you.
SVR 24 is better predictor of cure in Cirrhosis complicated HCV
Detailed Answer:
Hello Sir,
I understand your concern.
Let me explain the following lines to you.
You have been on Triple drug regimen of Sofusbuvir,Ribavarin and Peg-IF.
You also stated that you attained SVR12 in Dec 2014.This is a Good sign.
This indicates that you have shown good response to the drugs,as there is 2-log fold reduction of viral load.
Patients who develop SVR12 are the candidates for further extension of treatment to 24 weeks ,since only 65% of patients only go onto develop SVR12-which is only a an indication of early virological response.
The duration of treatment in presence of Cirrhosis is 24 months,hence SVR 24( an indication of late virological response) is attained in approx 97% patients(but not 100% here as well),who are considered potentially cured of the infection.
97% itself is an excellent score.
Hence SVR24 is a better predictor of possible cure of infection( with least risk of recurrence of infection) in patients with Cirrhosis.
Thank you.
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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