Question: Can IV iron infusions cause damage to the lungs or heart? I had iron infusions due to a low ferritin. About 2 weeks into treatment I developed shortness of breath. At times I would take deep gasping breaths. All my vital signs remained normal. I also felt like I had the flu, and had intense chills. I had a few episodes of severe itchiness at night. So my doctor stopped the infusions and sent me to see a pulmonologist to rule out PE/asthma. They were negative, my symptoms had improved, so they started me back with the infusions on a small dose. Later that night I started with the breathing again. I was for sure it was the iron. I took some benadryl, but it didn't help, so I took some Prednisone which seemed to help. I spoke with my hematologist and he said it was not a reaction to the iron. I began to feel somewhat better and decided to go to an allergist to get tested for iron allergy. I showed no histamine response on the skin test, so they put a patch on my skin to leave on for 48hours. About 12 hours later, I had the breathing issue happen again. I called the doctor and he said he didn't think it was an allergy. That was back in Sept. Unfortunately these symptoms have only gotten worse and I am seeing a pulmonologist and going to see a cardiologist because now I am having tachycardia, fatigue with slight exertion. I know it sounds crazy but I am trying to figure out if iron could have a connection to these problems, because I had none of these symptoms prior.