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Can Amitriptyline, Codeine, Naproxen And Morphine Cause Sedation?

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Posted on Mon, 3 Oct 2016
Question: My son XXXX went to A&E last night with severe stomach pains. His LFTs were abnormal. He was given morphine in the ambulance. He also took extra Lansoprazole, amytriptilene, paracetamol, codeine phosphate, and naproxen before calling for help. Today XXXX is extremely drowsy and can barely keep his eyes open. He has often been given morphine in the past without so much reaction. He has recently been taking Buspirone . Please advise.
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Answered by Dr. Chintan Solanki (1 hour later)
Brief Answer:
Can be due to multiple medicines

Detailed Answer:
Hello,

Thanks for writing to us. I can understand your concern for your son.

He has taken multiple medicines which can cause sedaton. Amitryptiline, codeine and naproxen with added morphine can make person drowsy.
One cause of XXXX drowsiness is this. If he is hospitalised and other vital parameters are normal, no need to worry.

Other important possibility is abnormal liver functions. If liver abnormality is severe, excessive urea can affect brain and cause drowsiness. We must rule out this cause. Please tell me detail report of liver function tests.

Hope I have answered your query, I will be happy to help further.

Regards,
Dr Chintan Solanki.
Note: Revert back with your health reports to get further guidance on your gastric problems. Click here.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Chintan Solanki

Psychiatrist

Practicing since :2007

Answered : 2406 Questions

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Can Amitriptyline, Codeine, Naproxen And Morphine Cause Sedation?

Brief Answer: Can be due to multiple medicines Detailed Answer: Hello, Thanks for writing to us. I can understand your concern for your son. He has taken multiple medicines which can cause sedaton. Amitryptiline, codeine and naproxen with added morphine can make person drowsy. One cause of XXXX drowsiness is this. If he is hospitalised and other vital parameters are normal, no need to worry. Other important possibility is abnormal liver functions. If liver abnormality is severe, excessive urea can affect brain and cause drowsiness. We must rule out this cause. Please tell me detail report of liver function tests. Hope I have answered your query, I will be happy to help further. Regards, Dr Chintan Solanki.