Togaviruses

What is Togaviruses?

The Togaviridae are a family of viruses, including the following genera:

  • Genus Alphavirus; type species: Sindbis virus, Eastern equine encephalitis virus, Western equine encephalitis virus, Venezuelan equine encephalitis virus, Ross River virus, O'nyong'nyong virus, Chikungunya, Semliki Forest virus
  • Genus Rubivirus; type species: Rubella virus

The Togaviridae family belong to group IV of the Baltimore classification of viruses. The genome is linear, single-stranded, positive sense RNA that is 10,000–12,000 nucleotides long. The 5'-terminus carries a methylated nucleotide cap and the 3'-terminus has a polyadenylated tail, therefore resembling cellular mRNA. The virus is enveloped and forms spherical particles (65–70 nm diameter), the capsid within is icosahedral, constructed of 240 monomers, having a triangulation number of 4. The receptors for binding are unknown, however the tropism is varied and it is known that the glycoprotein petal-like spikes act as attachment proteins. After virus attachment and entry into the cell, gene expression and replication takes place within the cytoplasm. The vector for Togaviridæ is primarily the mosquito, where replication of the virus occurs. The Togaviridae family is classified into Old World and New World viruses based on geographical distribution, although it’s likely that a few transoceanic crossings have occurred

Questions and answers on "Togaviruses"

Hi Doctor,
My wife is pregnant (10 weeks). She has gone through the blood test and result says:
Rubella IgG is 51 UI/ml and
Rubella IgM is 0.84...

doctor1 MD

Hello.

Thanks for posting your query.

This test suggest that at some point of time in past, she had rubella infection.

At present, she is not...

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Hi, I'm 34 years old & trying for our first baby. I have Anti Rubella test done as per advise from my gynae and was diagonosed Negative. I have...

doctor1 MD

Hello, yes you should wait at least for 3 months after rubella shots
In case you have any questions in future you can contact me directly on...

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Hi,
My wife is 12 weeks pregnant now. At 8 weeks she got her Rubella Result as Toxoplasma 0.50 and Rubella IgM Serum as 1.87. No IgG was checked at...

doctor1 MD

Hi,

Thanks for your query.

The normal range of the values differs in different labs for many tests.If you can attach the lab report here or mention...

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Recent questions on  Togaviruses

doctor1 MD

Hi



I had a rash (not rasied) on my limbs and torso a week ago. I went to doctors who took one look and said it was caused by a virus as it went...

doctor1 MD

Hi, I had a rubella 3 weeks ago, my last period was on 18/11/13 I still haven t got my period as yet, I have had period pains for 2 weeks now and 3...

doctor1 MD

My mom had chikungunya 2 years back. Since then she suffers from extreme pain in the hand finger joints and in the knees. Physio exercises are...

doctor1 MD

Hello,I m suffering from chikungunya joint pains. October I started with fever which subsided in 5 days following tht I m suffering frm joint...

doctor1 MD

My 2 year old daughter had a low fever last Sun (ranging btwn 99.9 and 101). No fever since. Then Weds night, during her bath I noticed she had...

doctor1 MD

I am 7 weeks pregnant. Today I got my blood report. Everything is within range except under chemistry test CO2 is 21(22-29mmol/L), and my rubella...

doctor1 MD

I had two miscarriages , the first being a molar pregnancy and the second a normal one. Both the pregnancies ended in missed abortions and had to...

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