What is Haptocorrin?
Haptocorrin also known as transcobalamin-1 (TC-1) is a protein that in humans is encoded by the TCN1 gene. The essential function of haptocorrin is protection of the acid-sensitive vitamin B12 while it moves through the stomach.
Haptocorrin (HC), also commonly known as the R-protein, or the R-factor, or previously referred to as transcobalamin I, is a unique glycoprotein produced by the salivary glands of the oral cavity, in response to ingestion of food. This protein binds strongly to vitamin B12 in what is perhaps an intricate yet necessary evolutionary mechanism to protect this vitamin from the acidic environment of the stomach.