Zolfresh

What is Zolfresh?

Zolpidem (brand names Ambien, Ambien CR, Intermezzo, Stilnox, Stilnoct, Sublinox, Hypnogen, Zonadin, Sanval, Zolsana and Zolfresh) is a prescription medication used for the treatment of insomnia and some brain disorders. It is a short-acting nonbenzodiazepine hypnotic of the imidazopyridine class that potentiates GABA, an inhibitory neurotransmitter, by binding to GABAA receptors at the same location as benzodiazepines. It works quickly, usually within 15 minutes, and has a short half-life of two to three hours.

Zolpidem has not adequately demonstrated effectiveness in maintaining sleep, unless delivered in a controlled-release (CR) form. However, it is effective in initiating sleep. Its hypnotic effects are similar to those of the benzodiazepine class of drugs, but it is molecularly distinct from the classical benzodiazepine molecule and is classified as an imidazopyridine. Flumazenil, a benzodiazepine receptor antagonist, which is used for benzodiazepine overdose, can also reverse zolpidem's sedative/hypnotic and memory-impairing effects.

Zolpidem has slight muscle relaxant and anticonvulsant properties, but has not been approved for use in muscle relaxation or seizure prevention. This is because the dosage of drug needed to cause muscle relaxation is 10 times the sedating dose, and the dosage needed for preventing seizures is 20 times the sedating dose; high dosages are more likely to cause unpleasant side effects such as hallucinations and amnesia. Contrary to early studies, more recent research has indicated that zolpidem is in fact a potent anticonvulsant. The anticonvulsant effects are not realized until the normal dosage range has been surpassed (meaning sedation would still be a major side effect) but the threshold for this effect is now believed to be considerably lower than original estimates.

The United States patent for zolpidem was held by the French pharmaceutical corporation Sanofi-Aventis. On April 23, 2007, the U.S. Food and Drug Administration (FDA) approved 13 generic versions of zolpidem tartrate. Zolpidem is available from several generic manufacturers in the UK, as a generic from Sandoz in South Africa and TEVA in Israel, as well as from other manufacturers such as Ratiopharm and Takeda GmbH (both Germany).

On January 10, 2013, the Food and Drug Administration announced it is requiring the manufacturer of Ambien and Zolpimist to cut the recommended dosage for women in half, after laboratory studies showed that the medicines can leave patients drowsy in the morning and at risk for car accidents. The FDA recommended that manufacturers extend the new dosage cuts to men as well, who process the drug at a faster rate; however, the reasons men and women metabolize the drugs at different rates are still unknown. In May 2013, the FDA approved label changes specifying new dosage recommendations for zolpidem products because of concerns regarding next-morning impairment.

Questions and answers on "Zolfresh"

Hi doctor. Sir my doctor prescribes zolfresh 10mg for insomia and depression anexiety.whether it is safe...

doctor1 MD

Brief Answer:
Zolfresh is Well tolerated

Detailed Answer:
Hello, Sir.

I can certainly understand your concern.

Yes, the prescribed medications are...

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Hi i m 29 yr m taking zolfresht frw last three years m ruining my heatlt frw last six mnts my dosage getting higher to 3 pills if i suddenly quit...

doctor1 MD

Brief Answer:
You can stop but need to see a psychiatrist for sleep problem

Detailed Answer:
Dear Dhaliwal.
Thanks for using Healthcaremagic.

I...

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If i take 900 mg zolfresh with 30 mg alprax what happen next

doctor1 MD

Brief Answer:
It is toxic dose

Detailed Answer:
Hello,
Thanks for using Healthcaremagic.

900 mg of Zolfresh and 30 mg of Alprax can be toxic and...

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Recent questions on  Zolfresh

doctor1 MD

SIR I HAVE BEEN TAKING 2MG CLONAZEPAM SINCE 1998. MAY I BE TOLERENT TO IT? WITH IT I HAVE BEEN TAKING 400MG QUTIAPIN PLAIN +10MG ZOLFRESH+ 600MG...

doctor1 MD

SIR I HAVE BEEN TAKING CLONAZEPAM 2MG SINCE 1998.WITH OTHER DRUGS LIKE TRIKA ,PROTHEIDIN MIRTAZE QUTIAPIN SR RESPECTIVELY WITH NITROZEPAM REMITEX...

doctor1 MD

Sir I m taking 2.5mg clonazepam +10mg zolfresh+400mg quetiapin plain+Gabaneuron 600mg SR and I got sufficient sleep and no fatigue . So should I...

doctor1 MD

hello doctor, my age is 23 and my weight is 50kgs and my height is 5.6 feet . from the last 2 weeks iam feeling depression because of job tension ,...

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